Design and Fabrication of an Engineered Bone Graft System (EBGS) by combining a composite scaffold and growth factor delivery system

结合复合支架和生长因子输送系统的工程骨移植系统（EBGS）的设计和制造

• 批准号: DP0989000
• 负责人: Prof Dietmar W. Hutmacher
• 金额: $ 22.84万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0989000
• 关键词: Design; Fabrication; Engineered; Bone; Graft

The lifetime risk for long bone fractures in Caucasians over the age of 50 is 17% for women and 6% for men. The prevalence of age-related fractures - and with it higher mortality rates due to complications following bone fractures - is therefore bound to increase over the coming decades. There is clearly a great need for therapies that take age-related changes into consideration, in particular the diminishing capacity of bone to heal with age. In an effort to address the therapeutic challenges of providing bone grafts, we aim to mesh two leading-edge technologies to design and fabricate an Engineered Bone Graft System (EBGS) system.

50岁以上的高加索人患长骨骨折的终生风险女性为17%，男性为6%。因此，在未来几十年里，与年龄相关的骨折的患病率——以及随之而来的骨折并发症导致的更高死亡率——必然会增加。显然，我们非常需要将与年龄相关的变化考虑在内的治疗方法，特别是随着年龄的增长，骨骼的愈合能力正在下降。为了解决提供骨移植的治疗挑战，我们的目标是结合两种前沿技术来设计和制造工程化骨移植系统（EBGS）系统。