CAREER: Elaborate Biomimetic Architectures

职业：精心设计的仿生架构

• 批准号: 0645361
• 负责人: Kent Kirshenbaum
• 金额: $ 57.5万
• 依托单位: New York University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-15 至 2012-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0645361&HistoricalAwards=false
• 关键词: CAREER; Elaborate; Biomimetic; Architectures

With the support of this CAREER award from the Organic and Macromolecular Chemistry Program, Professor Kent Kirshenbaum of New York University will pursue fundamental research in biomimetic chemistry by establishing new approaches for the study of folding in synthetic polymers. The ability to control precisely the architecture of complex chemical structures in three dimensions will provide molecules with sophisticated properties, such as specific molecular recognition and catalysis. The project will explore the design, synthesis, characterization and applications of a versatile family of protein mimics: sequence-specific N-substituted glycine polymers, also termed 'peptoids'. Some peptoid sequences have been shown to adopt stable helical conformations. The research program will focus upon this class of compounds since peptoids can effectively mimic more complex secondary and tertiary structures. The efforts will include the introduction of macrocyclic constraints to enforce peptoid conformational stability, design of novel folding motifs, enzymatic ligation of peptoid fragments, synthesis of peptoid macromolecules, and the structural characterization of folded peptoids. An enhanced understanding of macromolecular folding and its application in the design of functional chemical structures will be developed.With this CAREER award from the Organic and Macromolecular Chemistry Program, Professor Kirshenbaum will utilize experimental approaches in his research that will span the disciplines of bioorganic chemistry, physical chemistry and macromolecular engineering. This project will yield broader impacts by enhancing the discovery of chemical structures suitable for diverse materials and biomedical applications. The research program will provide an excellent training environment for undergraduate and graduate students to obtain skills in fields ranging from bionanotechnology to organic synthesis and drug design. Professor Kirshenbaum will establish an innovative approach to introduce topics in Macromolecular Chemistry to students from diverse backgrounds in the New York City Public School system. Working in partnership with New York University's Steinhardt School of Education, educational modules in 'Molecular Gastronomy' will be developed. Demonstrations utilizing unusual and delicious preparations of food polymers will allow students to learn that we perform chemical reactions in our kitchens on a daily basis; that the organization of molecules can be subjected to our control; and that Chemistry has an influence in every aspect of what we breathe, drink and eat.

在有机和高分子化学计划的职业奖的支持下，纽约大学的肯特·柯申鲍姆教授将通过建立合成聚合物折叠研究的新方法来进行仿生化学的基础研究。精确控制三维复杂化学结构体系的能力将为分子提供复杂的特性，如特定的分子识别和催化作用。该项目将探索蛋白质模拟物的多功能家族的设计，合成，表征和应用：序列特异性N-取代甘氨酸聚合物，也称为“类肽”。一些类肽序列已显示出采用稳定的螺旋构象。该研究计划将重点关注这类化合物，因为类肽可以有效地模拟更复杂的二级和三级结构。这些努力将包括引入大环约束来加强类肽构象稳定性，设计新的折叠基序，类肽片段的酶促连接，类肽大分子的合成以及折叠类肽的结构表征。通过有机和高分子化学计划的职业奖，Kirshenbaum教授将利用实验方法进行研究，研究领域涵盖生物有机化学、物理化学和高分子工程。该项目将产生更广泛的影响，通过加强适合不同材料和生物医学应用的化学结构的发现。该研究计划将为本科生和研究生提供良好的培训环境，以获得从生物纳米技术到有机合成和药物设计等领域的技能。Kirshenbaum教授将建立一种创新的方法，向来自纽约市公立学校系统不同背景的学生介绍高分子化学的主题。与纽约大学斯坦哈特教育学院合作，将开发“分子美食学”的教育模块。利用食物聚合物的不寻常和美味的准备演示将让学生了解到，我们每天都在厨房里进行化学反应;分子的组织可以受到我们的控制;化学对我们呼吸，饮用和食用的各个方面都有影响。