CAREER: Bioinorganic Chemistry on a Single-Molecule Basis

由无机、生物无机和有机金属化学项目颁发的CAREER奖支持康奈尔大学陈鹏教授在单分子基础上研究生物无机系统的工作。总体研究目标是利用单分子荧光技术来了解金属蛋白的动力学和功能，包括酪氨酸酶和铜伴侣蛋白。单分子方法将为表征生物无机系统开辟新的维度，并为酪氨酸酶和铜伴侣蛋白的功能和动力学提供独特的见解。对铜伴侣分子机制的认识将影响对铜转运相关疾病的认识和治疗。该计划的教育部分通过提供“Single vs. Mingle”研讨会来促进科学教育，该研讨会将通过一个特殊的科学研讨会为高中和社区大学的教师带来对单分子测量的欣赏。新的研究生课程、以研究为基础的本科教育材料和研究专题讨论会将提供跨学科的教育和培训。陈教授还将扩大女性和西班牙裔学生以及其他四年制大学生的参与，将这些学生纳入他的研究和教育项目。

This CAREER award by the Inorganic, Bioinorganic, and Organometallic Chemistry program supports work by Professor Peng Chen at Cornell University to study bioinorganic systems on a single-molecule basis. The overall research objective is to harness single-molecule fluorescence techniques to understand the dynamics and functions of metalloproteins including tyrosinase and copper chaperones. The single-molecule methods will open new dimensions in characterizing bioinorganic systems and provide unique insights into tyrosinase and copper chaperone functions and dynamics that are not available. The mechanistic knowledge on copper chaperones will impact the understanding and treatment of copper transport related diseases. The educational component of the program promotes science education by providing a "Single vs. Mingle" workshop which will bring an appreciation of single molecule measurements to high school and community college teachers through a special science workshop. A new graduate course, research-based undergraduate education materials, and a research symposium will provide interdisciplinary education and training. Professor Chen will also broaden the participation of female and Hispanic students, as well as other four-year college students, by including these students in his research and educational programs.