CAREER: Bioinorganic Chemistry on a Single-Molecule Basis

职业：单分子基础上的生物无机化学

• 批准号: 0645392
• 负责人: Peng Chen
• 金额: $ 55.5万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0645392&HistoricalAwards=false
• 关键词: CAREER; Bioinorganic; Chemistry; Single; Molecule

This CAREER award by the Inorganic, Bioinorganic, and Organometallic Chemistry program supports work by Professor Peng Chen at Cornell University to study bioinorganic systems on a single-molecule basis. The overall research objective is to harness single-molecule fluorescence techniques to understand the dynamics and functions of metalloproteins including tyrosinase and copper chaperones. The single-molecule methods will open new dimensions in characterizing bioinorganic systems and provide unique insights into tyrosinase and copper chaperone functions and dynamics that are not available. The mechanistic knowledge on copper chaperones will impact the understanding and treatment of copper transport related diseases. The educational component of the program promotes science education by providing a "Single vs. Mingle" workshop which will bring an appreciation of single molecule measurements to high school and community college teachers through a special science workshop. A new graduate course, research-based undergraduate education materials, and a research symposium will provide interdisciplinary education and training. Professor Chen will also broaden the participation of female and Hispanic students, as well as other four-year college students, by including these students in his research and educational programs.

这个由无机，生物无机和有机化学计划颁发的职业奖支持康奈尔大学Peng Chen教授在单分子基础上研究生物无机系统的工作。 总体研究目标是利用单分子荧光技术来了解金属蛋白（包括酪氨酸酶和铜分子伴侣）的动力学和功能。 单分子方法将开辟新的维度，在表征生物无机系统，并提供独特的见解酪氨酸酶和铜分子伴侣的功能和动力学是不可用的。 对铜分子伴侣机制的认识将影响对铜转运相关疾病的理解和治疗。 该计划的教育部分通过提供“单一与混合”研讨会来促进科学教育，该研讨会将通过特殊的科学研讨会为高中和社区大学教师带来对单分子测量的欣赏。 一个新的研究生课程，以研究为基础的本科教育材料，和研究研讨会将提供跨学科的教育和培训。 陈教授还将扩大女性和西班牙裔学生以及其他四年制大学生的参与，将这些学生纳入他的研究和教育计划。