CAREER: Metal-Ligand Multi-Electron Reactivity: Exploring the Chemistry of d0 Metal Complexes with Redox-Active Ligands

职业：金属配体多电子反应性：探索 d0 金属配合物与氧化还原活性配体的化学性质

• 批准号: 0645685
• 负责人: Alan Heyduk
• 金额: $ 55.5万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2012-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0645685&HistoricalAwards=false
• 关键词: CAREER; Metal; Ligand; Multi; Electron

This CAREER award by the Inorganic, Bioinorganic and Organometallic Chemistry Program supports work by Professor Alan F. Heyduk at the University of California-Irvine to develop two-electron reactivity for transition metal complexes with formal d0 metal electron counts and the use of ligand-based redox activities. The desired reactivities of these titanium, zirconium and halfnium metal complexes include oxidative addition, reductive elimination, and atom- and group-transfer reactions. These reactions are essentially unprecedented for these metals, so their elucidation will provide new reactivity patterns for use in catalyst design. The elaboration of new C-H bond functionalization strategies could impact the synthesis of commodity, pharmaceutical, and fine chemicals by providing a mild method for introducing nitrogen or oxygen containing functional groups into simple hydrocarbon substrates. The broader impacts of the research program include the scientific training and education of undergraduate and graduate researchers and students. Students will pursue new and original solutions to chemical problems while acquiring the technical skills that will make them competitive for future jobs in academia or the chemical industry. Beyond the laboratory, Professor Heyduk will further students' understanding of alternative energy strategies through a Freshman Seminar Course and UCI's California State Summer School for Mathematics and Science COSMOS program. Further, in collaboration with middle-school science teachers at schools near UC Irvine, Professor Heyduk is designing scientific experiments that introduce young students to experimental science to encourage them to think about scientific principles in the context of observation and data collection and to implement these principles in the construction of logical conclusions.

这项由无机化学、生物无机化学和金属有机化学计划颁发的职业奖支持加州大学欧文分校的Alan F.Heyduk教授为过渡金属络合物开发具有正式d0金属电子计数的双电子反应性和使用基于配体的氧化还原活性所做的工作。这些钛、锆和半金属络合物的预期反应性包括氧化加成、还原消除以及原子和基团转移反应。这些反应对于这些金属来说基本上是史无前例的，因此它们的阐明将为催化剂设计提供新的反应模式。新的C-H键官能化策略的研究为在简单碳氢化合物底物中引入含氮或含氧官能团提供了一种温和的方法，从而可能影响商品、药物和精细化学品的合成。该研究计划的更广泛影响包括对本科生和研究生研究人员和学生的科学培训和教育。学生将寻求化学问题的新的和原创的解决方案，同时获得使他们在未来的学术界或化学工业的工作中具有竞争力的技术技能。在实验室之外，Heyduk教授将通过新生研讨会课程和加州州立大学数学与科学宇宙暑期学校项目，进一步加深学生对替代能源战略的理解。此外，Heyduk教授与加州大学欧文分校附近学校的中学科学教师合作，正在设计科学实验，向年轻学生介绍实验科学，鼓励他们在观察和数据收集的背景下思考科学原理，并在构建逻辑结论时实施这些原则。