CAREER: Metal-Ligand Multi-Electron Reactivity: Exploring the Chemistry of d0 Metal Complexes with Redox-Active Ligands

职业：金属配体多电子反应性：探索 d0 金属配合物与氧化还原活性配体的化学性质

• 批准号: 0645685
• 负责人: Alan Heyduk
• 金额: $ 55.5万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2012-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0645685&HistoricalAwards=false
• 关键词: CAREER; Metal; Ligand; Multi; Electron

This CAREER award by the Inorganic, Bioinorganic and Organometallic Chemistry Program supports work by Professor Alan F. Heyduk at the University of California-Irvine to develop two-electron reactivity for transition metal complexes with formal d0 metal electron counts and the use of ligand-based redox activities. The desired reactivities of these titanium, zirconium and halfnium metal complexes include oxidative addition, reductive elimination, and atom- and group-transfer reactions. These reactions are essentially unprecedented for these metals, so their elucidation will provide new reactivity patterns for use in catalyst design. The elaboration of new C-H bond functionalization strategies could impact the synthesis of commodity, pharmaceutical, and fine chemicals by providing a mild method for introducing nitrogen or oxygen containing functional groups into simple hydrocarbon substrates. The broader impacts of the research program include the scientific training and education of undergraduate and graduate researchers and students. Students will pursue new and original solutions to chemical problems while acquiring the technical skills that will make them competitive for future jobs in academia or the chemical industry. Beyond the laboratory, Professor Heyduk will further students' understanding of alternative energy strategies through a Freshman Seminar Course and UCI's California State Summer School for Mathematics and Science COSMOS program. Further, in collaboration with middle-school science teachers at schools near UC Irvine, Professor Heyduk is designing scientific experiments that introduce young students to experimental science to encourage them to think about scientific principles in the context of observation and data collection and to implement these principles in the construction of logical conclusions.

无机，生物促是有机和有机金属化学计划的这一职业奖支持加利福尼亚大学 - 艾尔文大学的Alan F. Heyduk教授，为正式的D0金属电子计数和基于配体的氧化还原活性的使用，为过渡金属配合物开发两电子反应性。这些钛，锆和半nium金属配合物的所需反应性包括氧化添加，还原性消除以及原子和基团转移反应。 对于这些金属，这些反应本质上是前所未有的，因此它们的阐明将为催化剂设计提供新的反应性模式。 新的C-H键官能化策略的阐述可能会通过提供一种轻度的方法来影响商品，药物和细化学物质的合成，以将含氮或含氧官能基团引入简单的碳氢化合物底物中。 研究计划的更广泛影响包括本科和研究生研究人员和学生的科学培训和教育。 学生将寻求新的和原始的化学问题解决方案，同时获得技术技能，这将使他们在学术界或化学工业的未来工作中有竞争力。 除了实验室之外，海杜克教授将通过新生研讨会和UCI的加利福尼亚州数学和科学宇宙暑期学校进一步了解替代能源策略。 此外，在与加州大学尔湾分校附近学校的中学科学教师合作，Heyduk教授正在设计科学实验，这些实验将年轻学生介绍到实验科学上，以鼓励他们在观察和数据收集的背景下思考科学原理，并在逻辑结论的构建中实施这些原则。