CAREER: Spectroscopic Studies of Membrane Protein Folding

职业:膜蛋白折叠的光谱研究

基本信息

  • 批准号:
    0645720
  • 负责人:
  • 金额:
    $ 59.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-04-15 至 2014-03-31
  • 项目状态:
    已结题

项目摘要

In this award, funded by the Experimental Physical Chemistry Program of the Chemistry Division and the Molecular Biophysics Program of the Division of Molecular and Cellular Biology of the Biology Directorate, Prof. Judy E. Kim of the University of California, San Diego, and her graduate and undergraduate student colleagues will work to develop a better understanding of the mechanics of the folding, insertion and aggregation of membrane-bound proteins in biological systems. Prof. Kim and her group propose to do this with a powerful suite of spectroscopic tools, including steady state and time-resolved resonance emission spectroscopy (fluorescence, phosphorescence, and UV resonance Raman) along with fluorescence correlation spectroscopy.Membrane proteins are believed to comprise roughly 30% of all cellular proteins, and these serve important biological functions as gates, pumps, receptors, energy transducers, etc. Prof. Kim will also develop new biophysically-oriented courses (undergraduate and graduate,) and she will work to bring biophysical topics (e.g. protein misfolding and how it relates to Alzheimer's and Parkinson's disease) to a wider audience, through community outreach efforts.
在这个奖项,由化学部的实验物理化学计划和分子生物物理计划的分子和细胞生物学部的生物理事会,教授朱迪E。加州大学圣地亚哥分校的Kim和她的研究生和本科生同事将致力于更好地理解生物系统中膜结合蛋白质的折叠、插入和聚集机制。 Kim教授和她的团队建议使用一套强大的光谱工具来完成这项工作,包括稳态和时间分辨共振发射光谱(荧光、磷光和UV共振拉曼)沿着荧光相关光谱。膜蛋白被认为包括所有细胞蛋白的大约30%,并且这些蛋白作为门、泵、受体、能量转换器、金教授还将开发新的生物物理学课程(本科生和研究生),她将致力于通过社区外展工作将生物物理学主题(例如蛋白质错误折叠及其与阿尔茨海默氏症和帕金森氏症的关系)带给更广泛的受众。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Judy Kim其他文献

Narrating the "what" and "why" of our moral actions
讲述我们道德行为的“内容”和“原因”
A Mechanism of Regulation of Hypoxia-Inducible Factor 1 Alpha by Nitric Oxide
  • DOI:
  • 发表时间:
    2014-09
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Judy Kim
  • 通讯作者:
    Judy Kim
Improved health care transition for young adults with developmental disabilities referred from designated transition clinics.
改善从指定过渡诊所转诊的患有发育障碍的年轻人的医疗保健过渡。
  • DOI:
    10.2139/ssrn.4002249
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ellen Fremion;Rachel Cowley;J. Berens;Kristen A Staggers;K. J. Kemere;Judy Kim;Elisha Acosta;C. Peacock
  • 通讯作者:
    C. Peacock
The HSP70 Interaction with Phosphatidyl Serine on Membranes is the Initial Step its Release Into the Extracellular Medium
  • DOI:
    10.1016/j.bpj.2011.11.1300
  • 发表时间:
    2012-01-31
  • 期刊:
  • 影响因子:
  • 作者:
    Jonathan Okerblom;Michael R. Williams;David M. Cauvi;Diana Schlamadinger;Judy Kim;Nelson Arispe;Antonio De Maio
  • 通讯作者:
    Antonio De Maio
Inhibition of hypoxia-inducible factor 1α accumulation by glyceryl trinitrate and cyclic guanosine monophosphate
三硝酸甘油酯和环磷酸鸟苷抑制缺氧诱导因子 1α 的积累
  • DOI:
    10.1042/bsr20192345
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    4
  • 作者:
    Judy Kim;I. Barsoum;Harrison Loh;J. Paré;D. Siemens;C. Graham
  • 通讯作者:
    C. Graham

Judy Kim的其他文献

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{{ truncateString('Judy Kim', 18)}}的其他基金

Membrane Protein Folding
膜蛋白折叠
  • 批准号:
    2004081
  • 财政年份:
    2020
  • 资助金额:
    $ 59.5万
  • 项目类别:
    Standard Grant
Structure and Dynamics of Radical Intermediates in Biological Electron Transfer Reactions
生物电子转移反应中自由基中间体的结构和动力学
  • 批准号:
    1363255
  • 财政年份:
    2014
  • 资助金额:
    $ 59.5万
  • 项目类别:
    Continuing Grant
Structure and Dynamics of Radical Intermediates in Biological Electron Transfer Reactions
生物电子转移反应中自由基中间体的结构和动力学
  • 批准号:
    0911766
  • 财政年份:
    2009
  • 资助金额:
    $ 59.5万
  • 项目类别:
    Continuing Grant

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