CAREER: Spectroscopic Studies of Membrane Protein Folding

该奖项由美国加州大学圣地亚哥分校的朱迪·e·金（Judy E. Kim）教授和她的研究生和本科生同事共同资助，由美国生物学部化学学部的实验物理化学项目和分子与细胞生物学学部的分子生物物理学项目资助，他们将致力于更好地理解生物系统中膜结合蛋白的折叠、插入和聚集机制。Kim教授和她的团队建议使用一套强大的光谱工具来实现这一目标，包括稳态和时间分辨共振发射光谱（荧光、磷光和紫外共振拉曼）以及荧光相关光谱。膜蛋白被认为约占所有细胞蛋白的30%，它们具有重要的生物功能，如门、泵、受体、能量传感器等。Kim教授还将开发新的生物物理导向课程（本科和研究生），她将通过社区外展努力，将生物物理主题（例如蛋白质错误折叠及其与阿尔茨海默氏症和帕金森病的关系）带给更广泛的受众。

In this award, funded by the Experimental Physical Chemistry Program of the Chemistry Division and the Molecular Biophysics Program of the Division of Molecular and Cellular Biology of the Biology Directorate, Prof. Judy E. Kim of the University of California, San Diego, and her graduate and undergraduate student colleagues will work to develop a better understanding of the mechanics of the folding, insertion and aggregation of membrane-bound proteins in biological systems. Prof. Kim and her group propose to do this with a powerful suite of spectroscopic tools, including steady state and time-resolved resonance emission spectroscopy (fluorescence, phosphorescence, and UV resonance Raman) along with fluorescence correlation spectroscopy.Membrane proteins are believed to comprise roughly 30% of all cellular proteins, and these serve important biological functions as gates, pumps, receptors, energy transducers, etc. Prof. Kim will also develop new biophysically-oriented courses (undergraduate and graduate,) and she will work to bring biophysical topics (e.g. protein misfolding and how it relates to Alzheimer's and Parkinson's disease) to a wider audience, through community outreach efforts.