CAREER: Spectroscopic Studies of Membrane Protein Folding

该奖项由化学部的实验物理化学项目和生物局分子和细胞生物学部门的分子生物物理学项目资助，加州大学圣地亚哥分校的朱迪·E·金教授和她的研究生和本科生同事将致力于更好地理解生物系统中膜结合蛋白质的折叠、插入和聚集的机制。Kim教授和她的团队建议使用一套强大的光谱工具来实现这一点，包括稳态和时间分辨的共振发射光谱(荧光、磷光和UV共振拉曼)以及荧光相关光谱。膜蛋白据信约占所有细胞蛋白质的30%，这些蛋白质具有重要的生物学功能，如门、泵、受体、能量转换器等。Kim教授还将开发新的面向生物物理学的课程(本科生和研究生)，她将致力于将生物物理主题(例如蛋白质错误折叠及其与阿尔茨海默氏症和帕金森氏病的关系)带给更广泛的受众。通过社区外展工作。

In this award, funded by the Experimental Physical Chemistry Program of the Chemistry Division and the Molecular Biophysics Program of the Division of Molecular and Cellular Biology of the Biology Directorate, Prof. Judy E. Kim of the University of California, San Diego, and her graduate and undergraduate student colleagues will work to develop a better understanding of the mechanics of the folding, insertion and aggregation of membrane-bound proteins in biological systems. Prof. Kim and her group propose to do this with a powerful suite of spectroscopic tools, including steady state and time-resolved resonance emission spectroscopy (fluorescence, phosphorescence, and UV resonance Raman) along with fluorescence correlation spectroscopy.Membrane proteins are believed to comprise roughly 30% of all cellular proteins, and these serve important biological functions as gates, pumps, receptors, energy transducers, etc. Prof. Kim will also develop new biophysically-oriented courses (undergraduate and graduate,) and she will work to bring biophysical topics (e.g. protein misfolding and how it relates to Alzheimer's and Parkinson's disease) to a wider audience, through community outreach efforts.