CAREER: The Design and Utilization of Nanoscale Objects for Applications in Medicine and Materials Science

职业：纳米级物体的设计和利用在医学和材料科学中的应用

• 批准号: 0645737
• 负责人: Eva Harth
• 金额: $ 47.8万
• 依托单位: Vanderbilt University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-15 至 2012-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0645737&HistoricalAwards=false
• 关键词: CAREER; Design; Utilization; Nanoscale; Objects

With the support of the Organic and Macromolecular Chemistry Program in the Chemistry Division, Professor Eva M. Harth, of the Chemistry Department at the Vanderbilt University, will perform research on two synthetically related but conceptually quite distinct projects, the first on development of multifunctional polymeric nanoparticles for drug delivery, and the second polymeric nanoparticles for magnetic resonance imaging. The bioinspired nanoparticles are prepared in a top-down approach where functionalizations are introduced to a basic nanoparticle and in a bottom-up approach where further specifications are introduced on the linear precursor level. The new generation of dendritic molecular transporters will allow delivery of bioactive cargo, such as developed nanocarriers, small molecules, peptides and genes into specific sub cellular locations (nucleus or cytosol). Also proposed is the creation of complex materials composed of conducting polymers using intramolecular crosslinking methods to create functional, distinctive particles with well-defined dimensions. In a novel approach semiconducting crosslinking units will be the core units of semiconducting star polymers with large nanoscale dimensions. The use of lanthanides in hydrophilic star polymers will provide powerful bimodal imaging reagents for MRI applications. With the support of the Organic and Macromolecular Chemistry Program in the Chemistry Division, Professor Harth will pursue a multi-faceted, collaborative research plan involving the design and synthesis of functionalized nanoobjects to provide versatile platforms for cancer therapeutics, vaccine development, gene delivery, and imaging reagents in nanomedicine. The educational strategy will incorporate a coherent, systemic education and outreach plan that incorporates the research program with emphasis on addressing the underrepresentation of females and minorities in the fields of nanomedicine and soft materials science.

在化学系有机和高分子化学计划的支持下，范德比尔特大学化学系的伊娃·M·哈思教授将对两个合成上相关但概念上截然不同的项目进行研究，第一个项目是开发用于药物输送的多功能聚合物纳米颗粒，第二个项目是用于磁共振成像的聚合物纳米颗粒。生物灵感纳米粒子的制备方法是自上而下的方法，即在基本纳米颗粒中引入官能化，以及自下而上的方法，其中在线性前体水平上引入进一步的规范。新一代树枝状分子转运体将允许将生物活性货物，如已开发的纳米载体、小分子、多肽和基因输送到特定的亚细胞位置(细胞核或胞浆)。还提出了利用分子内交联方法创建由导电聚合物组成的复杂材料，以创建具有明确尺寸的功能、独特的粒子。在一种新的方法中，半导体交联单元将成为具有大纳米尺度的半导体星形聚合物的核心单元。稀土元素在亲水性星形聚合物中的应用将为磁共振成像应用提供强大的双峰成像试剂。在化学系有机和高分子化学项目的支持下，哈思教授将开展一项多方面的合作研究计划，涉及设计和合成功能化纳米对象，为纳米医学中的癌症治疗、疫苗开发、基因输送和成像试剂提供多功能平台。教育战略将包括一个连贯的、系统的教育和推广计划，其中包括研究计划，重点是解决纳米医学和软材料科学领域中女性和少数族裔代表性不足的问题。