CAREER: New Titanium-based Methods and Strategies for Organic Synthesis

本课题主要研究钛介导的（硅氧基）炔环化反应和基于Kulinkovich环丙烷化/环丙醇开孔的两步亚基偶联反应。这些新方法在复杂分子合成中的应用将通过两萜内酯J和螺络辛的全合成来证明。多步合成将作为一个平台，将新材料引入到本科和研究生有机化学课程中。为了更好地向学生传达多步骤有机合成的原理，兴奋和意义，我们将开发基于网络的学习工具，并组织工业科学家参观讲座。在有机和大分子化学项目的CAREER奖的支持下，科罗拉多大学博尔德分校化学和生物化学系的Andrew J. Phillips教授正在开发合成复杂有机分子的新方法。追求这一研究计划是由有机合成进一步的方法和战略进步的重要性支撑的。这一领域的进步将对有机合成领域做出根本性的贡献，最终这些进步将以各种方式对社会产生更广泛的影响，例如提供更便宜的药品、农用化学品和材料。在反应设计和效率方面的战略进展也可导致污染和资源支出的大幅减少。Phillips教授将通过引入新的相关课程内容、开发基于网络的学习工具，以及邀请工业科学家参观讲座等多维方法，加强本科和研究生阶段的有机化学课程。

This research project is focused on the development of titanium-mediated (silyloxy)enyne cyclizations and a two-step subunit coupling based on Kulinkovich cyclopropanation / cyclopropanol opening. The application of these new methods to complex molecule synthesis will be demonstrated by total syntheses of amphidinolide J and spirolaxine. Multistep synthesis will be used as a platform for the introduction of new material into the undergraduate and graduate organic chemistry curriculum. In order to better convey the principles, excitement, and significance of multistep organic synthesis to students, web-based learning tools will be developed and lecture visits by industrial scientists will be organized.With the support of this CAREER award from the Organic and Macromolecular Chemistry Program, Professor Andrew J. Phillips, of the Department of Chemistry and Biochemistry at the University of Colorado - Boulder, is developing new methods for the synthesis of complex organic molecules. The pursuit of this research plan is underpinned by the importance of further methodological and strategic advances in organic synthesis. Advances in this area will represent a fundamental contribution to the field of organic synthesis, and ultimately such advances have a broader impact on society in diverse ways such as providing improved/cheaper medicines, agrochemicals, and materials. Strategic advances in reaction design and efficiency can also result in substantially decreased pollution and resource expenditure. Professor Phillips will enhance the organic chemistry curriculum at both the undergraduate and graduate levels through a multi-dimensional approach involving the introduction of new and relevant course content, the development of web-based learning tools, and the initiation of lecture visits by industrial scientists.