CAREER: New Titanium-based Methods and Strategies for Organic Synthesis

该研究项目的重点是钛介导的（硅氧基）烯炔环化和基于Kulinkovich环丙烷化/环丙醇开环的两步亚基偶联的发展。这些新方法在复杂分子合成中的应用将通过两个化合物的全合成得到验证。多步合成将被用来作为一个平台，引入到本科和研究生有机化学课程的新材料。为了更好地向学生传达多步有机合成的原理、兴奋点和重要性，将开发基于网络的学习工具，并组织工业科学家进行讲座访问。在有机和高分子化学项目的CAREER奖的支持下，科罗拉多大学-博尔德分校化学和生物化学系的Andrew J.菲利普斯教授，正在开发合成复杂有机分子的新方法。这一研究计划的追求是由有机合成的进一步方法和战略进步的重要性所支撑的。这一领域的进展将对有机合成领域做出根本性的贡献，最终这些进展将以多种方式对社会产生更广泛的影响，例如提供更好/更便宜的药物，农用化学品和材料。在反应设计和效率方面的战略性进步也可以导致污染和资源消耗的大幅减少。教授菲利普斯将提高有机化学课程在本科生和研究生水平，通过一个多维的方法，涉及新的和相关的课程内容的介绍，基于网络的学习工具的开发，并通过工业科学家的讲座访问的启动。

This research project is focused on the development of titanium-mediated (silyloxy)enyne cyclizations and a two-step subunit coupling based on Kulinkovich cyclopropanation / cyclopropanol opening. The application of these new methods to complex molecule synthesis will be demonstrated by total syntheses of amphidinolide J and spirolaxine. Multistep synthesis will be used as a platform for the introduction of new material into the undergraduate and graduate organic chemistry curriculum. In order to better convey the principles, excitement, and significance of multistep organic synthesis to students, web-based learning tools will be developed and lecture visits by industrial scientists will be organized.With the support of this CAREER award from the Organic and Macromolecular Chemistry Program, Professor Andrew J. Phillips, of the Department of Chemistry and Biochemistry at the University of Colorado - Boulder, is developing new methods for the synthesis of complex organic molecules. The pursuit of this research plan is underpinned by the importance of further methodological and strategic advances in organic synthesis. Advances in this area will represent a fundamental contribution to the field of organic synthesis, and ultimately such advances have a broader impact on society in diverse ways such as providing improved/cheaper medicines, agrochemicals, and materials. Strategic advances in reaction design and efficiency can also result in substantially decreased pollution and resource expenditure. Professor Phillips will enhance the organic chemistry curriculum at both the undergraduate and graduate levels through a multi-dimensional approach involving the introduction of new and relevant course content, the development of web-based learning tools, and the initiation of lecture visits by industrial scientists.