MeshWorks - an innovative bimodal trabecular mesh and new titanium alloy for spinal implants

MeshWorks - 用于脊柱植入物的创新双峰小梁网和新型钛合金

• 批准号: 43749
• 金额: $ 72.26万
• 依托单位: ALLOYED LIMITED
• 依托单位国家: 英国
• 项目类别: Study
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=43749
• 关键词: MeshWorks; innovative; bimodal; trabecular; mesh

Orthopaedic degeneration is a normal part of aging, anticipated to affect ~80% of the world's population. The Office for National Statisticsestimates the UK's proportion of over 65s will rise to 20.7% by 2027, so the financial and societal impacts can only increase.In the past decade approximately two million people in the UK had a metallic device implanted to replace a bone or joint in their body, with surgeries increasing at 7%/year. The most common surgical intervention is hip or knee replacement followed by spinal fusion implants, then implants to other joints. Around 250,000 procedures are conducted in the UK each year. However, around 50% will have non-ideal results, with 40% of patients still unable to return to work up to 4 years after surgery. Up to 20% will require a revision, with 75% of these due to the implant failing.OxMet has designed a new alloy for use in medical implants that eliminates current problems such as:* High stiffness: stiff implants which 'stress shield' surrounding bone, causing bone cells to weaken and die, loosening the implant.* Cytotoxicity: Ti64, one of the most common implant materials, contains cytotoxic vanadium and aluminium.* Compatibility with Additive Manufacture: Current implant materials are not designed for use with additive manufacturing, resulting in defects and fracturing.OxMet and Betatype have designed a new mesh that more closely matches the structure of cancellous bone. Closer matching improves implant osseointegration, both in terms of speed and strength, reducing failure rates. The design takes advantage of Betatypes' bespoke proprietary algorithms that are both quicker and improve control.OxMet and Betatype will work with the University of Birmingham to provide proof-of-concept evidence for the improved effectiveness of the combined alloy and mesh.

骨科退化是衰老的正常现象，预计将影响世界约 80% 的人口。英国国家统计局估计，到 2027 年，英国 65 岁以上人口的比例将上升至 20.7%，因此财务和社会影响只会越来越大。在过去十年中，英国大约有 200 万人植入了金属装置以替代体内的骨骼或关节，手术数量以每年 7% 的速度增长。最常见的手术干预是髋关节或膝关节置换术，然后进行脊柱融合植入物，然后植入其他关节。英国每年进行约 250,000 例手术。然而，约 50% 的患者术后效果并不理想，其中 40% 的患者在术后 4 年内仍无法重返工作岗位。多达 20% 的问题需要修复，其中 75% 是由于植入物失效造成的。OxMet 设计了一种用于医疗植入物的新型合金，可消除当前的问题，例如：* 高刚度：坚硬的植入物会对周围的骨骼产生“压力屏蔽”，导致骨细胞衰弱和死亡，从而使植入物松动。* 细胞毒性：Ti64 是最常见的植入材料之一，含有细胞毒性钒和 铝。* 与增材制造的兼容性：当前的植入材料并非设计用于增材制造，会导致缺陷和断裂。OxMet 和 Betatype 设计了一种新的网格，与松质骨的结构更加匹配。更紧密的匹配可以提高种植体骨整合的速度和强度，从而降低失败率。该设计利用了 Betatypes 的定制专有算法，既速度更快，又改善了控制。OxMet 和 Betatype 将与伯明翰大学合作，为提高组合合金和网格的有效性提供概念验证证据。