SGER Creating Catalytic Monodisperse Particles Using Microreactors

摘要提案编号：cts -0647257首席研究员：McQuade， D. tyler合作单位：康奈尔大学捐赠基金提案题目：SGER：利用微反应器制造催化单分散粒子智力优势：合成分子使我们的生活更安全、更健康、更快乐。不幸的是，许多这些改善生命的化合物的合成是困难和浪费的。该提案的目的是开发催化剂，通过设计多个催化剂在单个容器或单个微反应器中顺序操作的过程，使有机合成能够大大提高效率。这些多催化剂系统通过最大限度地提高中间体预处理和分离之前发生的化学转化次数来提高效率。实现这一目标需要开发支持均相催化剂的新材料。本研究使用一个简单的微反应器在流动中制造单分散硅氧烷，目的是更深入地了解界面科学、聚合和流体动力学。由于使用微反应器制造新材料是一个新的研究领域，任何对这个新兴领域的贡献都是一个重大的进步。更广泛的影响：由于这项研究而产生的独特材料将在许多学术领域和工业领域产生广泛的影响。这些材料将用于促进更有效的药物制剂合成。这些材料还将用于支持新药物的发现，高温离子交换树脂，以及其他需要高表面积和高温稳定性的应用。从这项研究中获得的知识也将有助于研究流体动力学和材料的研究人员。本文将重点研究微尺度系统中流动诱导分散与自组织之间的相互作用。复杂的实验程序涉及PI实验室中最先进的仪器。在未来，所进行的测量将被用来挑战目前的模型，这些模型估计了三维混沌流中颗粒迁移引起的浓度分布。这项工作将为研究生和本科生提供研究机会，其成果将纳入研究生水平的课程。

ABSTRACTProposal Number: CTS-0647257Principal Investigator: McQuade, D. TylerAffiliation: Cornell University - EndowProposal Title: SGER: Creating Catalytic Monodisperse Particles Using Microreactors Intellectual Merit:Synthetic molecules make our lives safer, healthier, and happier. Unfortunately, the synthesis of many of these life-improving compounds is difficult and wasteful. The aim of the proposal is to develop catalysts that will enable organic synthesis can be made substantially more efficient by designing processes in which multiple catalysts operate sequentially in a single vessel or in a single microreactor. These multi-catalyst systems increase efficiency by maximizing the number of chemical transformations that occur before work-up and isolation of intermediates. Realizing this goal requires the development of new materials for supporting homogeneous catalysts.This proposed research uses a simple microreactor to make monodisperse siloxanes in flow with the goal of a deeper understanding of interfacial science, polymerization, and fluid dynamics. Since the use of microreactors to create novel materials is a new field of research, any contribution to this emerging area is a significant advance forward.Broader Impacts:The unique materials created as a result of this research will have broad impact in a number of academic fields as well as in industry. These materials will be used to facilitate more efficient pharmaceutical agent synthesis. These materials will also be used as supports for new drug discovery, for high-temperature ion exchange resins, and for other applications where high surface area and high temperature stability are needed. The knowledge gained from this research will also aid researchers who study fluid dynamics and materials.The proposed research will focus of the interplay between flow-induced dispersion and self-organization in microscale systems. The complex experimental procedures involve state-of-the-art instruments available in the PI's laboratory. The measurements performed will, in the future, be used to challenge current models that estimate the concentration profiles resulting from particle migration in 3D chaotic flows. The work will provide graduate and undergraduate research opportunities, and outcomes will be incorporated into a graduate level course.