SGER Creating Catalytic Monodisperse Particles Using Microreactors

SGER 使用微反应器制造催化单分散颗粒

• 批准号: 0647257
• 负责人: David McQuade
• 金额: $ 5万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-10-01 至 2007-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0647257&HistoricalAwards=false
• 关键词: SGER; Creating; Catalytic; Monodisperse; Particles

ABSTRACTProposal Number: CTS-0647257Principal Investigator: McQuade, D. TylerAffiliation: Cornell University - EndowProposal Title: SGER: Creating Catalytic Monodisperse Particles Using Microreactors Intellectual Merit:Synthetic molecules make our lives safer, healthier, and happier. Unfortunately, the synthesis of many of these life-improving compounds is difficult and wasteful. The aim of the proposal is to develop catalysts that will enable organic synthesis can be made substantially more efficient by designing processes in which multiple catalysts operate sequentially in a single vessel or in a single microreactor. These multi-catalyst systems increase efficiency by maximizing the number of chemical transformations that occur before work-up and isolation of intermediates. Realizing this goal requires the development of new materials for supporting homogeneous catalysts.This proposed research uses a simple microreactor to make monodisperse siloxanes in flow with the goal of a deeper understanding of interfacial science, polymerization, and fluid dynamics. Since the use of microreactors to create novel materials is a new field of research, any contribution to this emerging area is a significant advance forward.Broader Impacts:The unique materials created as a result of this research will have broad impact in a number of academic fields as well as in industry. These materials will be used to facilitate more efficient pharmaceutical agent synthesis. These materials will also be used as supports for new drug discovery, for high-temperature ion exchange resins, and for other applications where high surface area and high temperature stability are needed. The knowledge gained from this research will also aid researchers who study fluid dynamics and materials.The proposed research will focus of the interplay between flow-induced dispersion and self-organization in microscale systems. The complex experimental procedures involve state-of-the-art instruments available in the PI's laboratory. The measurements performed will, in the future, be used to challenge current models that estimate the concentration profiles resulting from particle migration in 3D chaotic flows. The work will provide graduate and undergraduate research opportunities, and outcomes will be incorporated into a graduate level course.

摘要提案编号：CTS-0647257主要研究者：McQuade，D.泰勒所属机构：康奈尔大学- EndowProposal标题：SGER：使用微反应器创建催化单分散颗粒智力优点：合成分子使我们的生活更安全，更健康，更快乐。不幸的是，许多这些改善生活的化合物的合成是困难和浪费的。该提案的目的是开发催化剂，使有机合成可以通过设计在单个容器或单个微反应器中顺序操作多种催化剂的方法而变得更加有效。这些多催化剂系统通过最大化在后处理和分离中间体之前发生的化学转化的数量来提高效率。实现这一目标需要开发新的材料来支持均相催化剂。这项研究使用一个简单的微反应器来使单分散硅氧烷流动，目的是更深入地了解界面科学，聚合和流体动力学。由于利用微反应器制造新型材料是一个新的研究领域，因此对这一新兴领域的任何贡献都是一个重大的进步。更广泛的影响：这项研究所产生的独特材料将在许多学术领域以及工业领域产生广泛的影响。这些材料将用于促进更有效的药剂合成。这些材料还将用于新药开发、高温离子交换树脂以及其他需要高表面积和高温稳定性的应用。从这项研究中获得的知识也将有助于研究流体动力学和材料的研究人员。拟议的研究将集中在微尺度系统中的流动诱导分散和自组织之间的相互作用。复杂的实验程序涉及PI实验室中可用的最先进仪器。所进行的测量，在未来，将被用来挑战目前的模型，估计在三维混沌流中的颗粒迁移造成的浓度分布。这项工作将提供研究生和本科生的研究机会，其成果将纳入研究生课程。