Multi-Catalyst Systems: Non-covalent Bifunctional Catalytic Complexes

该项目将继续致力于开发将两种或两种以上催化剂结合在一个系统中的方法，目的是使已知反应更快、更有选择性，并使新反应成为可能。虽然现有的多催化剂系统以更低的成本产生更高效和选择性的反应，但它们目前的使用范围有限。通过将它们的应用范围扩大到更多的反应中，预计整个合成领域将产生重大的效益。该项目侧重于双功能催化剂（在一个分子中具有两个催化特征），它可以导致更快的反应速率，具有更高的对映性和化学选择性以及更高的收率。通过这个奖项，有机和大分子化学项目支持佛罗里达州立大学化学系D. Tyler McQuade教授的研究。McQuade教授的研究工作围绕着多催化剂体系的发展。世界范围内生活水平的提高导致对救生小分子的需求增加，但这些分子的获取受到能源和原材料成本上升的威胁。这项工作的成功将导致合成效率的提高和反应速度的显著加快，这将有助于满足全球对这些重要分子的需求

This project will continue work on the development of methods that combine two or more catalysts in one system with the goal of making known reactions faster and more selective and also enabling new reactions. While existing multi-catalyst systems yield more efficient and selective reactions at less expense, their current range is limited. By broadening their use to even more reactions, significant benefits across the field of synthesis are expected. This project focuses on bifunctional catalysts (with two catalytic features in one molecule), which can lead to faster reaction rates with greater enantio- and chemoselectivity as well as better yields.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor D. Tyler McQuade of the Department of Chemistry at Florida State University. Professor McQuade's research efforts revolve around the development of multi-catalyst systems. The rising standard of living worldwide has resulted in greater demand for life-saving small molecules, but access to these molecules is threatened by rising costs of energy and raw materials. Success of the proposed work would lead to advances in synthetic efficiency and significantly accelerated reaction rates that would help to satisfy the global demand for these important molecules