SENSORS: A New Approach to Recognition Element Synthesis and Integration

传感器：识别元件合成和集成的新方法

• 批准号: 0329899
• 负责人: David McQuade
• 金额: --
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0329899&HistoricalAwards=false
• 关键词: SENSORS; New; Approach; Recognition; Element

Chemical warfare agents are insidious elements of modern weaponry. These highly toxic agents can be delivered by complex methods such as guided missiles or by simple devices such as the bags of sarin solution left on a Tokyo subway in 1995. Nerve gases such as sarin are easily prepared, making them readily accessible weapons of mass destruction. Their acute toxicity requires that precautions and antidotes be taken before exposure occurs. Sensors with high sensitivity and rapid response can ensure the safety of civilians and military personnel. The research results of this NSF SENSORS proposal will provide not only unique sensors for nerve agent detection, but also advances in basic recognition science.(I) The intellectual merit of the proposed activity: The research consists of the development of peptide/dye conjugates designed to rapidly react with and respond to G and VX type chemical warfare agents. Despite many years of active research, no general platform has emerged that allows development and optimization of specific sensors. A method to detect G and VX agents using a general strategy for sensor design will be developed. This approach could provide sensors for biomedical, food science, and environmental applications as well. Amplification is necessary to detect non-lethal doses of chemical warfare agents. The peptide/dye conjugates will be incorporated into a new light harvesting-based amplification scheme that is a development at the interface of photophysics and synthetic chemistry. This research will provide a better understanding of how to control energy migration within solids, which will also have implications for photovoltaic cell and organic light emitting diode design.(II) The broader impacts resulting from the proposed activity: Despite great advances in science and engineering, our ability to monitor and quantify air, water and food quality is rudimentary. In the future, inexpensive sensors will continuously monitor the environment for pollutants, chemical and biological warfare agents, and other toxins. This proposal outlines steps towards measuring chemical warfare agents using robust and inexpensive means. The proposed sensors should be easily and inexpensively incorporated into portable sensors for use in shopping malls, airports, office buildings and soldier uniforms to monitor for low concentrations of nerve agents. This project is interdisciplinary and will train a student at the interface of photophysics, materials science, and chemistry. The student will learn how to synthesize organic dyes and polymers, how to create and characterize thin films, and how to measure and quantify the photophysical properties. Students with this training shouldbe sought after by companies interested in telecommunications, organic LEDs, photonics, and sensors.The PI also plans to create workshops and programs to educate children and elementary and high school teachers. An important element of this project is how light interacts with matter. Optical computing, optical communications, photovoltaics, and other light harvesting devices are becoming important areas of commerce. As such, elementary and high school students should be exposed to basic concepts of absorption, luminescence, and energy migration. As a step toward this goal, the PI will create "light interacting with matter" workshops, hands-on demonstrations and training opportunities for both students and teachers.

化学战剂是现代武器的潜在要素。这些剧毒制剂可以通过复杂的方法，如制导导弹或简单的装置，如1995年留在东京地铁上的沙林溶液袋。沙林等神经毒气很容易制备，使其成为容易获得的大规模杀伤性武器。其急性毒性要求在接触前采取预防措施和解毒剂。具有高灵敏度和快速反应的传感器可以确保平民和军事人员的安全。NSF SENSORS提案的研究成果不仅将为神经毒剂检测提供独特的传感器，还将推动基础识别科学的发展。(I)拟议活动的知识价值：研究包括开发肽/染料结合物，旨在与G和VX型化学战剂迅速反应并作出反应。尽管经过多年的积极研究，但还没有出现允许开发和优化特定传感器的通用平台。 将开发一种使用传感器设计的一般策略来检测G和VX代理的方法。这种方法也可以为生物医学，食品科学和环境应用提供传感器。放大是必要的，以检测非致命剂量的化学战剂。肽/染料缀合物将被纳入一个新的基于光收获的扩增方案，这是在生物物理学和合成化学的界面上的发展。这项研究将提供一个更好的了解如何控制能量迁移的固体，这也将对光伏电池和有机发光二极管设计的影响。(II)拟议活动产生的更广泛影响：尽管科学和工程取得了巨大进步，但我们监测和量化空气、水和食品质量的能力仍处于初级阶段。未来，廉价的传感器将持续监测环境中的污染物、化学和生物战剂以及其他毒素。该提案概述了使用可靠和廉价手段测量化学战剂的步骤。所提出的传感器应该容易且廉价地并入便携式传感器中，用于购物中心、机场、办公楼和士兵制服，以监测低浓度的神经毒剂。 这个项目是跨学科的，将培养一个学生在物理学，材料科学和化学的接口。学生将学习如何合成有机染料和聚合物，如何创建和表征薄膜，以及如何测量和量化物理特性。接受过这种培训的学生应该会受到对电信、有机LED、光子学和传感器感兴趣的公司的追捧。PI还计划开设讲习班和项目，教育儿童和中小学教师。这个项目的一个重要元素是光如何与物质相互作用。光计算、光通信、光电子学和其他光捕获设备正在成为重要的商业领域。因此，小学生和高中生应该接触吸收，发光和能量迁移的基本概念。作为实现这一目标的一步，PI将为学生和教师创造“光与物质相互作用”的研讨会、动手示范和培训机会。