Collaborative Research: Electrowetting Micro Array Printing System for Bioactive Tissue Construct Manufacturing
合作研究:用于生物活性组织结构制造的电润湿微阵列打印系统
基本信息
- 批准号:0654244
- 负责人:
- 金额:$ 3.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-04-01 至 2010-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The objective of this collaborative research project is to investigate the process of electrowetting on dielectric as an advanced manufacturing technology for tissue engineering. An electrowetting-based microfluidics array printing system will be created to rapidly print chitosan hydrogel and other biomaterials to build micro porous scaffolds with predefined structures, cells, and growth factors. The project addresses fundamental challenges to biocompatible dispensing of hydrogels, living cells, and growth factors, to mimic tissue extra cellular matrix architecture and support cell proliferation. Specifically, the investigators will: (1) characterize chitosan hydrogel, in terms of its mechanical strength, rheology, solidification, manufacturability, biocompatibility, and ability to support cell proliferation; (2) model, design, and demonstrate the generation of sub-nanoliter hydrogel droplets from an on-chip reservoir through electrowetting, addressing issues of biocompatibility and droplet dispensing; and (3) demonstrate and characterize the sterility, biocompatibility, and manufacturing precision of an intelligent system including software control, actuation, multiple reservoirs, and printing arrays, to manufacture scaffolds based on a computer-aided design model of myocardial tissue. If successful, this project will enable tissue engineers to optimize mechanical, transport, material, and biological properties of a soft tissue engineering scaffold, with a degree of structural control, fine resolution (10 microns) and embedded cells and growth factors not currently available. In this project, a group of graduate and undergraduate senior students will be trained in advanced manufacturing technology and tissue engineering. Several project-based learning modules will be created to strengthen the undergraduate mechanical and biomedical engineering curricula. The project will also be used in outreach workshops for local high school and community college students, including many underrepresented minority students, to showcase high-tech mechanical and electrical engineering applications in biotechnology.
本合作研究计画的目的是探讨电湿润技术作为组织工程先进制造技术的制程。 将创建基于电润湿的微流体阵列打印系统,以快速打印壳聚糖水凝胶和其他生物材料,以构建具有预定义结构、细胞和生长因子的微孔支架。该项目解决了水凝胶,活细胞和生长因子的生物相容性分配的基本挑战,以模拟组织细胞外基质结构并支持细胞增殖。具体而言,研究人员将:(1)表征壳聚糖水凝胶的机械强度,流变学,固化,可制造性,生物相容性和支持细胞增殖的能力;(2)建模,设计和演示通过电润湿从芯片上的储液器产生亚纳升水凝胶液滴,解决生物相容性和液滴分配问题;和(3)证明和表征智能系统的无菌性、生物相容性和制造精度,所述智能系统包括软件控制、致动、多个储存器和打印阵列,以基于心肌组织的计算机辅助设计模型制造支架。如果成功,该项目将使组织工程师能够优化软组织工程支架的机械,运输,材料和生物学特性,具有一定程度的结构控制,精细分辨率(10微米)和嵌入的细胞和生长因子,目前还没有。在这个项目中,一组研究生和本科高年级学生将接受先进制造技术和组织工程方面的培训。 将创建几个基于项目的学习模块,以加强本科机械和生物医学工程课程。该项目还将用于为当地高中和社区大学学生,包括许多代表性不足的少数民族学生举办的外联讲习班,以展示高科技机械和电气工程在生物技术中的应用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
David Wootton其他文献
From Trace Generation to Visualization: A Performance Framework for Distributed Parallel Systems
从跟踪生成到可视化:分布式并行系统的性能框架
- DOI:
10.1109/sc.2000.10050 - 发表时间:
2000 - 期刊:
- 影响因子:0
- 作者:
C. Wu;Anthony Bolmarcich;M. Snir;David Wootton;F. Parpia;Anthony Chan;E. Lusk;W. Gropp - 通讯作者:
W. Gropp
David Wootton的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('David Wootton', 18)}}的其他基金
MRI-R2: Acquisition of Endoscopic Particle Image Velocimetry System and Multiprocessor Computer for Fluid Mechanics Research
MRI-R2:采集内窥镜粒子图像测速系统和多处理器计算机用于流体力学研究
- 批准号:
0959915 - 财政年份:2010
- 资助金额:
$ 3.37万 - 项目类别:
Standard Grant
GOALI/Collaborative Research: Design and Manufacturing of Bioactive Surgical Fixation Devices Using Injection Molding of Gradient Cellular Structures
GOALI/合作研究:利用梯度细胞结构注射成型设计和制造生物活性手术固定装置
- 批准号:
0800743 - 财政年份:2008
- 资助金额:
$ 3.37万 - 项目类别:
Standard Grant
相似国自然基金
Research on Quantum Field Theory without a Lagrangian Description
- 批准号:24ZR1403900
- 批准年份:2024
- 资助金额:0.0 万元
- 项目类别:省市级项目
Cell Research
- 批准号:31224802
- 批准年份:2012
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Cell Research
- 批准号:31024804
- 批准年份:2010
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Cell Research (细胞研究)
- 批准号:30824808
- 批准年份:2008
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Research on the Rapid Growth Mechanism of KDP Crystal
- 批准号:10774081
- 批准年份:2007
- 资助金额:45.0 万元
- 项目类别:面上项目
相似海外基金
Collaborative Research: REU Site: Earth and Planetary Science and Astrophysics REU at the American Museum of Natural History in Collaboration with the City University of New York
合作研究:REU 地点:地球与行星科学和天体物理学 REU 与纽约市立大学合作,位于美国自然历史博物馆
- 批准号:
2348998 - 财政年份:2025
- 资助金额:
$ 3.37万 - 项目类别:
Standard Grant
Collaborative Research: REU Site: Earth and Planetary Science and Astrophysics REU at the American Museum of Natural History in Collaboration with the City University of New York
合作研究:REU 地点:地球与行星科学和天体物理学 REU 与纽约市立大学合作,位于美国自然历史博物馆
- 批准号:
2348999 - 财政年份:2025
- 资助金额:
$ 3.37万 - 项目类别:
Standard Grant
Collaborative Research: Investigating Southern Ocean Sea Surface Temperatures and Freshening during the Late Pliocene and Pleistocene along the Antarctic Margin
合作研究:调查上新世晚期和更新世沿南极边缘的南大洋海面温度和新鲜度
- 批准号:
2313120 - 财政年份:2024
- 资助金额:
$ 3.37万 - 项目类别:
Standard Grant
NSF Engines Development Award: Utilizing space research, development and manufacturing to improve the human condition (OH)
NSF 发动机发展奖:利用太空研究、开发和制造来改善人类状况(OH)
- 批准号:
2314750 - 财政年份:2024
- 资助金额:
$ 3.37万 - 项目类别:
Cooperative Agreement
Doctoral Dissertation Research: How New Legal Doctrine Shapes Human-Environment Relations
博士论文研究:新法律学说如何塑造人类与环境的关系
- 批准号:
2315219 - 财政年份:2024
- 资助金额:
$ 3.37万 - 项目类别:
Standard Grant
Collaborative Research: Non-Linearity and Feedbacks in the Atmospheric Circulation Response to Increased Carbon Dioxide (CO2)
合作研究:大气环流对二氧化碳 (CO2) 增加的响应的非线性和反馈
- 批准号:
2335762 - 财政年份:2024
- 资助金额:
$ 3.37万 - 项目类别:
Standard Grant
Collaborative Research: Using Adaptive Lessons to Enhance Motivation, Cognitive Engagement, And Achievement Through Equitable Classroom Preparation
协作研究:通过公平的课堂准备,利用适应性课程来增强动机、认知参与和成就
- 批准号:
2335802 - 财政年份:2024
- 资助金额:
$ 3.37万 - 项目类别:
Standard Grant
Collaborative Research: Using Adaptive Lessons to Enhance Motivation, Cognitive Engagement, And Achievement Through Equitable Classroom Preparation
协作研究:通过公平的课堂准备,利用适应性课程来增强动机、认知参与和成就
- 批准号:
2335801 - 财政年份:2024
- 资助金额:
$ 3.37万 - 项目类别:
Standard Grant
Collaborative Research: Holocene biogeochemical evolution of Earth's largest lake system
合作研究:地球最大湖泊系统的全新世生物地球化学演化
- 批准号:
2336132 - 财政年份:2024
- 资助金额:
$ 3.37万 - 项目类别:
Standard Grant
CyberCorps Scholarship for Service: Building Research-minded Cyber Leaders
CyberCorps 服务奖学金:培养具有研究意识的网络领导者
- 批准号:
2336409 - 财政年份:2024
- 资助金额:
$ 3.37万 - 项目类别:
Continuing Grant