Genetic Risk contribution to Alcoholic chronic Pancreatitis (GRAP study)

慢性胰腺炎（CP）是一种进行性胰腺炎性疾病，可导致不可逆的器官损伤。发病率为每10万居民3.5-10人，由于这一相当高的发病率，CP对保健和社会系统造成了相当大的负担。在西方世界，酗酒是主要原因。然而，只有5%的酗酒者会患上CP。这一事实和家族聚集性表明存在遗传易感因素。为了评估酒精性CP的遗传因素，我们计划在2585例酒精性CP患者中进行全基因组关联研究（GWAS）。高通量全基因组扫描技术的出现允许对DNA序列变异进行系统分析，如先前的研究充分证明的。我们建立了一个泛欧洲酒精性CP工作组，汇集了来自欧洲各地的研究人员，收集了2.585份酒精性CP患者的DNA样本。我们计划进行病例对照全基因组关联分析。对照来自已建立的研究，并且已经进行了基因分型。基因分型和生物信息学和生物统计学分析将使用莱比锡LIFE中心的基础设施进行。

Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas leading to irreversible damage of the organ. Incidence rates are 3.5-10 per 100.000 inhabitants and due to this considerable incidence rate CP is responsible for a rather huge debit for health care and social systems. In the Western world alcohol abuse is the predominant contributor. However, only 5 % of alcoholics develop CP. This fact and familial clustering suggest the presence of genetic susceptibility factors. To evaluate the genetic contributors to alcoholic CP we plan to conduct a genome-wide association study (GWAS) in 2.585 patients with alcoholic CP. The advent of high throughput genome-wide scanning technologies allows a systematic analysis of DNA sequence variations as demonstrated sufficiently by former studies. We established a Pan-European working party on alcoholic CP assembling researchers from all over Europe that collected 2.585 DNA-samples of well phenotyped patients with alcoholic CP. We plan to perform a case-control genome-wide association analysis. Controls arise from established studies and are already genotyped. Genotyping and bioinformatical and biostatistical analysis will be conducted using the infrastructure of the LIFE-center in Leipzig.