Fracture Fabrication of Micro/Nano Patterned Microspheres

微/纳米图案微球的断裂制备

基本信息

项目摘要

Intellectual Merit: New possibilities would open in many fields if there were straightforward ways to manufacture microspheres with complex surface features. The challenge in accomplishing this goal is the lack of methods for manufacturing micro/nano features on three-dimensional micro-objects in a controlled, yet rapid, robust, and parallel process. This proposal takes inspiration from nature, where fracture of thin films is utilized to produce patterns such as features on cantaloupe skin that form as the surface is strained in response to growth of its interior, to develop a novel fracture-based manufacturing technology. Specifically, a combination of strain-induced fracturing of polymer-supported thin films, surface chemistry manipulations, microfluidics, colloidal assembly, and electroless deposition of metals is used to form micro/nano patterned microspheres. Manufacture of the desired features is guided by computational analysis of the mechanics of thin film fracture on microspheres. Broader Impact: Efficient manufacture of micro/nano-patterned microspheres will impact many fields such as preparation of photonic materials, study of rheology, development of novel electronic devices, and in the study and manipulation of biological cells. The technology will also impact micro/nano-manufacturing education because the visually striking, experimentally straightforward, and theoretically stimulating nature of the process makes it an inherently useful system to provide introductory hands-on laboratory experiences to students of all levels. This project will particularly focus on providing research opportunities for minority female engineering students and undergraduate students. The theories and experiments developed will also be incorporated into graduate courses in biomedical, mechanical, and materials engineering.
智力优势:如果有简单的方法来制造具有复杂表面特征的微球,那么在许多领域都将出现新的可能性。 实现这一目标的挑战是缺乏在受控但快速、稳健和并行的过程中在三维微物体上制造微/纳米特征的方法。 该提案从自然界中获得灵感,其中利用薄膜的断裂来产生图案,例如哈密瓜皮上的特征,这些特征随着其内部的生长而形成,以开发一种新颖的基于薄膜的制造技术。 具体地,使用聚合物支撑的薄膜的应变诱导断裂、表面化学操作、微流体、胶体组装和金属的无电沉积的组合来形成微/纳米图案化微球。 制造所需的功能是指导微球上的薄膜断裂力学的计算分析。更广泛的影响:微/纳米图案化微球的有效制造将影响许多领域,例如光子材料的制备、流变学研究、新型电子器件的开发以及生物细胞的研究和操纵。 该技术还将影响微/纳米制造教育,因为该过程的视觉冲击,实验简单和理论刺激的性质使其成为一个固有的有用系统,为各级学生提供介绍性的动手实验室经验。 该项目将特别侧重于为少数族裔女工科学生和本科生提供研究机会。 开发的理论和实验也将纳入生物医学,机械和材料工程的研究生课程。

项目成果

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Shuichi Takayama其他文献

The Spheroid Light Microscopy Image Atlas for morphometrical analysis of three-dimensional cell cultures
用于三维细胞培养形态计量分析的球体光镜图像图谱
  • DOI:
    10.1038/s41597-025-04441-x
  • 发表时间:
    2025-02-17
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Eva Blondeel;Arne Peirsman;Stephanie Vermeulen;Filippo Piccinini;Felix De Vuyst;Diogo Estêvão;Sayida Al-Jamei;Martina Bedeschi;Gastone Castellani;Tânia Cruz;Sándor Dedeyne;Maria José Oliveira;Satoru Kawakita;Huu Tuan Nguyen;Leoni A. Kunz-Schughart;Soojung Lee;Noemi Marino;Patrick Steigemann;Shuichi Takayama;Anna Tesei;Nina Zablowsky;Phillip Blondeel;Olivier De Wever
  • 通讯作者:
    Olivier De Wever
Microanalysis using surface modification and biphasic droplets
使用表面修饰和双相液滴的微观分析
  • DOI:
    10.1038/s41428-018-0050-x
  • 发表时间:
    2018-04-25
  • 期刊:
  • 影响因子:
    2.700
  • 作者:
    Taisuke Kojima;Shuichi Takayama
  • 通讯作者:
    Shuichi Takayama
Timing is everything: using fluidics to understand the role of temporal dynamics in cellular systems
  • DOI:
    10.1007/s10404-009-0413-x
  • 发表时间:
    2009-02-14
  • 期刊:
  • 影响因子:
    2.500
  • 作者:
    Andreja Jovic;Bryan Howell;Shuichi Takayama
  • 通讯作者:
    Shuichi Takayama
DNA linearization through confinement in nanofluidic channels
  • DOI:
    10.1007/s00216-008-1995-y
  • 发表时间:
    2008-03-14
  • 期刊:
  • 影响因子:
    3.800
  • 作者:
    Nicholas Douville;Dongeun Huh;Shuichi Takayama
  • 通讯作者:
    Shuichi Takayama
Patterning the topographical environment for mammalian cell culture using laminar flows in capillaries
利用毛细血管中的层流模拟哺乳动物细胞培养的地形环境

Shuichi Takayama的其他文献

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{{ truncateString('Shuichi Takayama', 18)}}的其他基金

I-Corps: High Efficiency Transduction to Improve Manufacture of Cell Therapeutics
I-Corps:高效转导以改善细胞治疗药物的生产
  • 批准号:
    1929805
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
I-Corps: SOLUTION MICROARRAY MULTIPLEXED BIOMARKER IMMUNOASSAYS
I-Corps:微阵列多重生物标志物免疫测定解决方案
  • 批准号:
    1243080
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
NER: Manufacture of Nanowire Patterned Microspheres
NER:纳米线图案微球的制造
  • 批准号:
    0403603
  • 财政年份:
    2004
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
CAREER: Biological Micro- and Nanotechnology Research and Education
职业:生物微纳米技术研究与教育
  • 批准号:
    0238625
  • 财政年份:
    2003
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant

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