OPTOFLUIDICS FOR NEXT GENERATION OF LABORATORY-ON-A-CHIP

0701729哥伦比亚大学Daniel Attinger面向下一代芯片实验室的光学流体学智能优点：拟议的研究将把多功能和超高速光学传感器与极其高效的流体处理技术集成到微流体芯片中。这些光流控芯片将执行化学和生物学的基本任务，如混合、纯化和蛋白质吸附。这些任务将以前所未有的频率执行和监测，接近兆赫的频率。该项目的创新将是开发占地面积为几微米的通用集成传感器，基于最先进的高质量因子光学纳米结构谐振器，开发基于新型界面和分段流动技术的快速流体混合。广泛影响：流体处理小型化和集成化的显著进步使数千个微通道和阀门能够在所谓的微流控芯片中大规模集成，用于粒子合成和基因组分析等新的化学和生物应用。在目前的微流控芯片中，工作频率受到基于扩散的混合的限制；另外，传感方法速度慢且体积大，许多方法需要显微镜和可视化设备。拟议中的光流控芯片集成了高分辨率光学传感器和快速微流控能力，预计将显著提高微流控芯片的处理能力，就像集成晶体管提高微电子芯片的处理能力一样。这一跨学科研究的教育组成部分包括理论和数值设计、器件微米和纳米制造以及流体和光学实验。该计划将支持两名研究生和本科生暑期研究体验(REU)活动。它涉及应用物理、机械、电气和生物医学工程等跨境课题。将为K-12学校教师开发关于光学流体、微流体和光学传感器的具体教育模块，并通过两个夏季讲习班向纽约大都市区布朗克斯区和哈莱姆区的少数族裔和代表性不足的学生介绍。

0701729Daniel Attinger, Columbia UniversityOptofluidics for Next Generation of Laboratory-On-A-ChipIntellectual Merit: The proposed research will integrate versatile and ultrafast optical sensors with extremely efficient fluid handling techniques into microfluidic chips. These optofluidics chips will perform tasks essential to chemistry and biology, such as mixing, purification, and protein adsorption. These tasks will be executed and monitored at unprecedented frequencies, close to MHz rates. The innovations of the project will be to develop universal integrated sensors with a footprint of a few micrometers, based on state-of-the-art high quality factor optical nanostructured resonators, and to develop fast fluidic mixing based on novel interfacial and segmented flow techniques.Broader Impact: Remarkable advances in the miniaturization and integration of fluid handling have allowed large-scale integration of thousands of microchannels and valves in so-called microfluidic chips for novel chemical and biological applications, such as particle synthesis and genomic analysis. In current microfluidic chips, the operation frequencies are limited by diffusion-based mixing; also, sensing methods are slow and bulky, many requiring a microscope and visualization setup. The proposed optofluidics chips, integrating high-resolution optical sensors with fast microfluidic capabilities, are expected to contribute significantly to increase the processing power of microfluidic chips, in a similar way that integrated transistors have improved the processing power of microelectronic chips. The educational components of this interdisciplinary research involve theory and numerical design, device micro- and nano-fabrication, as well as fluidic and optical experiments. This program will support two graduate students and summer Research Experience for Undergraduates (REU) activities. It involves cross-boundary topics in Applied Physics, Mechanical, Electrical and Biomedical Engineering. Specific education modules on optofluidics, microfluidics and optical sensors will be developed for K-12 school teachers and presented through two summer workshops for minorities and underrepresented students around the New York metropolitan area, in the Bronx and Harlem.