Characterization of Coronary Atherosclerotic Plaque in Ex-vivo Human Coronary Arteries Using High Definition Computed Tomography in Comparison to Intravascular Ultrasound, Optical Coherence Tomography and Histology

使用高清计算机断层扫描与血管内超声、光学相干断层扫描和组织学比较，对离体人冠状动脉中的冠状动脉粥样硬化斑块进行表征

• 批准号: 181311163
• 负责人: Dr. Harald Dirk Seifarth
• 金额: --
• 依托单位: Cardiovascular Research Center (CVRC)
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2011-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/181311163?language=en
• 关键词: Characterization; Coronary; Atherosclerotic; Plaque; Ex

Coronary heart disease is the manifestation of atherosclerosis in the coronary vessels. In the early stages of disease patients are asymptomatic. In nearly 50% of patients suffering from coronary heart disease, a coronary event is the primary manifestation of the disease. The majority of these events are caused by rupture of the atherosclerotic plaque followed by thrombotic occlusion of the vessel. A certain type of plaque, coined the vulnerable plaque, is especially prone to rupture. The plaques have been shown to have a thin fibrous cap covering a large lipid core. The identification these vulnerable plaques has been the subject of intense research. This includes advances such as intravascular ultrasound, thermography and optical coherence tomography. However, these are invasive techniques that are associated with a certain rate of complications. At he same time non-invasive techniques for coronary imaging such computed tomography (CT) have gained widespread acceptance in diagnosing coronary heart disease. The aim of the present study is to evaluate whether a new detector technology for cardiac CT that offers both an increased special resolution as well as the possibility to perform monochromatic reconstructions within the spectrum of the x-ray beam, can reliably identify these lipid rich plaques.

冠心病是冠状动脉粥样硬化的表现。在疾病的早期阶段，患者无症状。在近50%患有冠心病的患者中，冠状动脉事件是该疾病的主要表现。这些事件中的大多数是由动脉粥样硬化斑块破裂随后血管血栓性闭塞引起的。某种类型的斑块，被称为易损斑块，特别容易破裂。已显示斑块具有覆盖大脂质核心的薄纤维帽。识别这些脆弱的斑块一直是深入研究的主题。这包括血管内超声、热成像和光学相干断层扫描等方面的进展。然而，这些是与一定并发症率相关的侵入性技术。与此同时，用于冠状动脉成像的非侵入性技术，例如计算机断层扫描（CT），在诊断冠心病方面已获得广泛接受。本研究的目的是评估一种新的心脏CT检测器技术是否能够可靠地识别这些富含脂质的斑块，该技术既提供了更高的特殊分辨率，又可以在X射线束的光谱内进行单色重建。