Air Pollution, Coronary Events and Atherosclerotic Progression in a Susceptible Population

易感人群中的空气污染、冠状动脉事件和动脉粥样硬化进展

• 批准号: 10650319
• 负责人: Meng Wang
• 金额: $ 28.84万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-21 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10650319
• 关键词: 12-HETE; Acceleration; Address; Age; Air; Air Pollutants; Air Pollution; Algorithms; American; Angiography; Arterial Fatty Streak; Atherosclerosis; Biological; Biological Markers; Biological Process; Biometry; Blood; Blood Vessels; Carbon Black; Cardiovascular system; Caring; Cause of Death; Cessation of life; China; Clinic Visits; Clinical Management; Clinical assessments; Coronary; Coronary Arteriosclerosis; Coronary Stenosis; Coronary heart disease; Data; Development; Diameter; Disease; Disease Progression; Disparity; Environmental Exposure; Environmental Risk Factor; Epidemiology; Exposure to; Fatty acid glycerol esters; Functional disorder; Health Benefit; Health Policy; Health protection; Imaging technology; Individual; Indoor Air Pollution; Inflammation; Intervention; Joints; Knowledge; Lipid Peroxidation; Lipids; Longitudinal cohort study; Measures; Mediating; Modality; Modeling; Morbidity - disease rate; Morphology; Natural experiment; Nitrogen Oxides; Noise; Outcome; Oxidative Stress; Ozone; Participant; Particle Size; Particulate Matter; Pathway interactions; Patients; Play; Policies; Pollution; Population; Predisposition; Prevention; Public Health; Public Policy; Qualifying; Regulation; Risk; Role; Rupture; Site; Source; Stenosis; Thrombosis; Time; Toxic effect; X-Ray Computed Tomography; ambient air pollution; attenuation; calcification; cardiovascular health; clinical biomarkers; coarse particles; cohort; cooking; coronary calcium scoring; coronary event; critical period; evidence base; experience; fine particles; high risk; improved; indexing; indoor pollutant; inflammatory marker; insight; interest; mortality; multidisciplinary; novel; novel marker; novel strategies; phenotypic data; population based; progression risk; public health priorities; response; solid fuel; specific biomarkers; stressor; ultrafine particle; vascular inflammation

Abstract Cardiovascular health is a global public health priority. Atherosclerosis is the most common form of coronary heart diseases (CHD) which constitutes 17.5 million deaths worldwide annually. Globally, both outdoor and indoor air pollutants are known as major contributors to the burdens of CHD. Despite population-based evidence suggesting that exposure to ambient air pollutants and use of solid fuel for cooking causes increased mortality from CHD, there is little known about the impact of air pollution on CHD morbidity and progression. For example, the extent to which exposure to air pollution accelerates atherosclerosis, initiate plaque instability to rupture and develop coronary events, and the mechanistic pathways underneath are largely unknown. A better understanding of air pollutants as potential factors to the development and progression of this pervasive disease will be valuable for public health protection strategies, especially for susceptible population such as patients with atherosclerosis. Here we propose a longitudinal cohort study and present an overarching hypothesis that long-term exposure to air pollutants alter coronary biological process, accelerate disease progression, and contribute to CHD morbidity and mortality. This study builds upon a well-selected 3500 patients with atherosclerosis in Beijing retrieved from an existing cohort and will add two waves of clinic visits in 1100 subpopulation to examine disease progression. The cohort includes extensive data of novel subclinical markers from computed tomography angiography (CTA) reflecting plaque morphology, plaque vulnerability, vascular stenosis, and coronary inflammation, and also collects biomarkers related to their mechanistic pathways. We also propose to add state-of-the art air pollution exposure assessment to determine individual level of outdoor and indoor air pollution exposure of the highest quality to address our study hypotheses. Firstly, we will determine the impact of outdoor and indoor air pollution exposures on coronary events and total cardiovascular mortality. Secondly, we will investigate the effects of exposure to air pollution on atherosclerosis progression and high-risk plaque formation characterized by CTA outcomes. Thirdly, we will examine the effects of air pollution on biological markers of inflammation pathways and explore whether these pathways mediate any response of disease progression to air pollution exposure. Lastly, we will take the unique opportunity of the most stringent regulation period on air pollution in Beijing and assess whether long-term decline in ambient air pollution change the worsening of the disease progression and biological responses as our secondary hypothesis. Apart from the main analysis, we will also explore the potential of joint effects of air pollutant mixtures and independent effects of air pollution exposure from traffic noise on CHD. Findings from this study will not only extend scientific knowledge on air pollution and CHD physiopathology, but will provide information to guide public policy and inform clinical management for individuals at-risk of CHD.

摘要 心血管健康是全球公共卫生的优先事项。动脉粥样硬化是最常见的冠状动脉疾病。 每年全世界有1750万人死于心脏病。在全球范围内，包括户外和 室内空气污染物被认为是造成冠心病负担的主要因素。尽管以人口为基础 有证据表明，暴露在环境空气污染物中和使用固体燃料做饭的原因增加 关于空气污染对冠心病发病率和进展的影响，人们对此知之甚少。 例如，暴露在空气污染中会加速动脉粥样硬化、引发斑块不稳定的程度。 导致冠状动脉事件的破裂和发展，其机制在很大程度上是未知的。一个 更好地了解空气污染物是这种普遍存在的疾病发展和进展的潜在因素 疾病将对公共卫生保护战略有价值，特别是对易感人群，如 动脉粥样硬化的患者。在这里，我们提出了一项纵向队列研究，并提出了一个总体 假设长期暴露在空气污染物中会改变冠状动脉的生物学过程，加速疾病 进展，并导致冠心病的发病率和死亡率。这项研究建立在精心挑选的3500人的基础上 北京的动脉粥样硬化患者从现有队列中检索，并将增加两波临床就诊 在1100个亚群中检查疾病进展情况。该队列包括新亚临床的大量数据。 来自计算机断层血管成像(CTA)的标记物反映斑块形态、斑块脆弱性、 血管狭窄和冠脉炎症，并收集与其机制相关的生物标志物 小路。我们亦建议加入最先进的空气污染暴露评估，以确定个别人士 室外和室内空气污染水平暴露的最高质量来解决我们的研究假设。 首先，我们将确定室外和室内空气污染暴露对冠状动脉事件和总 心血管疾病死亡率。其次，我们将调查暴露于空气污染对动脉粥样硬化的影响 进展和以CTA结果为特征的高危斑块形成。第三，我们将研究 空气污染对炎症途径生物标志物的影响及探讨这些途径 调节疾病进展对空气污染暴露的任何反应。最后，我们将以独特的 以北京最严格的空气污染管制期为契机，评估是否长期 环境空气污染的减少改变了疾病进展和生物反应的恶化 我们的第二个假设。除了主要的分析外，我们还将探索空气联合作用的可能性 污染物混合及交通噪声空气污染暴露对冠心病的独立影响调查结果来自 这项研究不仅将扩展关于空气污染和冠心病生理病理学的科学知识，而且将提供 为冠心病高危人群提供指导公共政策和临床管理的信息。

项目成果

A Review of Road Traffic-Derived Non-Exhaust Particles: Emissions, Physicochemical Characteristics, Health Risks, and Mitigation Measures.

• DOI: 10.1021/acs.est.2c01072
• 发表时间: 2022-06-07
• 期刊: ENVIRONMENTAL SCIENCE & TECHNOLOGY
• 影响因子: 11.4
• 作者: Fussell, Julia C.;Franklin, Meredith;Green, David C.;Gustafsson, Mats;Harrison, Roy M.;Hicks, William;Kelly, Frank J.;Kishta, Franceska;Miller, Mark R.;Mudway, Ian S.;Oroumiyeh, Farzan;Selley, Liza;Wang, Meng;Zhu, Yifang
• 通讯作者: Zhu, Yifang

Modeling spatial variation of gaseous air pollutants and particulate matters in a Metropolitan area using mobile monitoring data.

• DOI: 10.1016/j.envres.2022.112858
• 发表时间: 2022-07
• 期刊: ENVIRONMENTAL RESEARCH
• 影响因子: 8.3
• 作者: Xu, Jia;Yang, Wen;Bai, Zhipeng;Zhang, Renyi;Zheng, Jun;Wang, Meng;Zhu, Tong
• 通讯作者: Zhu, Tong

Health benefits from the rapid reduction in ambient exposure to air pollutants after China's clean air actions: progress in efficacy and geographic equality.

• DOI: 10.1093/nsr/nwad263
• 发表时间: 2024-02
• 期刊: National science review
• 影响因子: 20.6

The short-term effect of ozone on pregnancy loss modified by temperature: Findings from a nationwide epidemiological study in the contiguous United States.

臭氧对受温度影响的妊娠丢失的短期影响：来自美国邻近地区的一项全国性流行病学研究的结果。

• DOI: 10.1016/j.scitotenv.2023.166088
• 发表时间: 2023
• 期刊: The Science of the total environment
• 作者: Tong,Mingkun;Wang,Meng;Li,Pengfei;Gong,Jicheng;Zhu,Tong;Xue,Tao
• 通讯作者: Xue,Tao