Comprehensive characterization of coronary atherosclerotic disease using photon-counting-detector dual-source CT and its impact on patient management
使用光子计数探测器双源 CT 全面表征冠状动脉粥样硬化疾病及其对患者管理的影响
基本信息
- 批准号:10592395
- 负责人:
- 金额:$ 67.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptionAdultAlgorithmsAnatomyAwardBlood VesselsCardiacClinicClinicalClinical ResearchCollaborationsComputed Tomography ScannersContrast MediaCoronaryCoronary ArteriosclerosisCoronary arteryDefectDiagnosisDoseElectronicsEngineeringEquipmentFamily suidaeGeometryGoalsHealthcareHeart failureHumanImageIndividualIodineLesionLow Dose RadiationMeasuresMorbidity - disease rateMyocardialMyocardial InfarctionMyocardial perfusionMyocardiumNoisePatientsPerfusionPhysicsPhysiologicalPredictive ValueRadiationRadiation Dose UnitReproducibilityResolutionSignal TransductionSocietiesSourceSpecimenStentsSudden DeathSystemTechniquesTechnologyTimeTranslatingUnited StatesUnited States National Institutes of HealthVisualizationWorkX-Ray Computed Tomographyalgorithm developmentcalcificationcardiac magnetic resonance imagingcardiac single photon emission computed tomographyclinically significantcoronary plaquecostdeep learningdensitydesigndetectordiagnostic valueheart imagingheart motionhigh riskhuman subjectimaging capabilitiesimprovedindustry partnerinjuredinnovationmortalitynon-invasive imagingnoninvasive diagnosisnovelperfusion imagingphoton-counting detectorporcine modelroutine practicesocietal costsspectral energyspectrographtechnology developmenttemporal measurementvasa vasorum
项目摘要
PROJECT SUMMARY/ABSTRACT
Coronary artery disease (CAD) remains the main cause of morbidity and mortality in the United States. Cardiac
CT provides fast non-invasive assessment of CAD with a high sensitivity and negative predictive value –
provided that the lumen can be visualized. However, heavily calcified or stented coronary segments are non-
assessable, precluding non-invasive diagnosis of flow-limiting coronary plaques in an estimated 2 million U.S.
adults. In addition, the spatial resolution of state-of-the-art CT systems is insufficient for robust visualization of
features associated with high risk plaques. Further, while CT can quantitatively evaluate the impact of
obstructive CAD on myocardial function using dynamic perfusion imaging, this requires relatively high patient
radiation doses, which has limited widespread adoption. Considering the high personal and societal cost of
CAD, robust, accurate, non-invasive imaging of calcified and stented coronary arteries, high-risk plaque
features, and myocardial perfusion defects in a single, low-radiation-dose exam is critically needed.
Built by Siemens Healthcare, a first-of-its-kind, whole-body, photon-counting-detector (PCD) CT system was
installed in 2014 at the Mayo Clinic. With support from NIH award EB016966, we showed that the increased
iodine contrast-to-noise ratio, decreased electronic noise, spectral imaging capabilities, and improved spatial
resolution of PCD-CT relative to commercial CT enabled us to accurately measure increased vasa vasorum
density in injured swine carotid arterial walls, demonstrating the exceptional potential of PCD-CT in vascular
imaging. Because this system lacks cardiac imaging capabilities, our objective is to develop and validate a
PCD dual-source (DS) CT system and novel imaging algorithms to accurately assess CAD in humans,
especially in patients with heavily calcified, stented, or high-risk plaques, and to identify patients with
myocardial perfusion defects. Our premise is that the established benefits of PCD-CT, used with a DS
geometry and advanced noise reduction and material decomposition algorithms, can meet these objectives.
Our proposal is significant in many ways: the technology developments will benefit all of CT imaging; robust,
accurate, non-invasive imaging of calcified and stented coronary arteries, high-risk plaque features, and
myocardial perfusion defects in a single, low-radiation-dose exam will obviate the need for additional imaging,
reducing the overall time and cost to comprehensively evaluate CAD and its clinical significance. To extend the
demonstrated benefits of PCDs to cardiac CT will require numerous physics, engineering, and algorithm
innovations, including novel noise reduction and material decomposition algorithms using energy, spatial and
temporal domain redundancies, as well as deep learning. These advances will culminate in a large clinical
study to demonstrate not merely that the images are “better,” as is so often done, but that PCD-DSCT provides
clinically-significant improvements in the diagnosis and management of patients with suspected CAD.
项目总结/文摘
项目成果
期刊论文数量(0)
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{{ truncateString('Shuai Leng', 18)}}的其他基金
Comprehensive characterization of coronary atherosclerotic disease using photon-counting-detector dual-source CT and its impact on patient management
使用光子计数探测器双源 CT 全面表征冠状动脉粥样硬化疾病及其对患者管理的影响
- 批准号:
10391327 - 财政年份:2020
- 资助金额:
$ 67.35万 - 项目类别:
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