Gold-based mitochondria targeted chemotherapeutics: mechanistic studies probing interactions with thiol and selenol containing proteins

金基线粒体靶向化疗：探讨与含硫醇和硒醇的蛋白质相互作用的机制研究

• 批准号: DP0986318
• 负责人: Prof Susan Berners-Price
• 金额: $ 22.85万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0986318
• 关键词: Gold; based; mitochondria; targeted; chemotherapeutics

Cancer affects one in four Australians and prostate cancer is the most commonly diagnosed and second leading cause of male cancer deaths, for which there is currently no effective treatment. Current chemotherapeutics must overcome drug resistance and lack of selectivity between tumour and normal cells. To circumvent these problems we are investigating gold-based compounds, which act by a novel mechanism. The research will lead to new strategies in the design of improved anticancer drugs, an important Australian research priority that will promote and maintain good health. Other benefits arise from training PhD students with interdisciplinary skills for Australian biotechnology industries.

癌症影响四分之一的澳大利亚人，前列腺癌是最常见的诊断和男性癌症死亡的第二大原因，目前没有有效的治疗方法。目前的化疗药物必须克服耐药性和肿瘤与正常细胞之间缺乏选择性。为了解决这些问题，我们正在研究金基化合物，它通过一种新的机制发挥作用。这项研究将导致在设计改进的抗癌药物方面的新战略，这是澳大利亚的一项重要研究优先事项，将促进和保持良好的健康。其他好处来自培养博士生与澳大利亚生物技术产业的跨学科技能。