Establishing the role of alpha-2-macroglobulin in quality control of extracellular protein folding

建立 α-2-巨球蛋白在细胞外蛋白质折叠质量控制中的作用

• 批准号: DP0984341
• 负责人: Prof Mark Wilson
• 金额: $ 3.16万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0984341
• 关键词: Establishing; role; alpha; macroglobulin; quality

The expected outcomes will provide important advances in understanding the role of alpha-2-macroglobulin (A2M) in maintaining the normal structure/function of extracellular proteins. This information may ultimately aid in the design of agents to be used to clear the body of pathological protein aggregates - potentially providing a direct economic benefit to Australia. The high novelty and broad significance of this work indicate that it will produce high-impact publications which will tangibly assist Australia being recognized as a major contributor to world research outcomes. This project will also provide a direct social benefit by training research students with the skills necessary to further the development of biological research in Australia.

预期的结果将为理解α-2-巨球蛋白（A2 M）在维持细胞外蛋白正常结构/功能中的作用提供重要进展。这些信息最终可能有助于设计用于清除体内病理性蛋白质聚集体的药物-可能为澳大利亚提供直接的经济利益。这项工作的高度新奇和广泛意义表明，它将产生高影响力的出版物，这将切实有助于澳大利亚被公认为世界研究成果的主要贡献者。该项目还将提供直接的社会效益，通过培训研究生，使其掌握促进澳大利亚生物研究发展所需的技能。