Defining systems that clear dangerous misfolded proteins from body fluids

定义从体液中清除危险的错误折叠蛋白质的系统

• 批准号: DP160100011
• 负责人: Prof Mark Wilson
• 金额: $ 31.73万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-05-16 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160100011
• 关键词: Defining; systems; clear; dangerous; misfolded

The project intends to establish how the human body defends itself against protein-folding related disease and loss of quality of life. Exposure to everyday physical and chemical stresses can cause proteins to lose their normal shape and become misfolded. Misfolded proteins are causally involved in human ageing and serious diseases (for example, Alzheimer's disease). However, the body does have a protective system that clears dangerous misfolded proteins from body fluids. Using cutting-edge approaches and a novel animal model, the project aims to establish how this system works. The outcomes are expected to improve understanding of the molecular processes affecting human ageing and disease and strengthen the framework needed to develop better strategies to combat these.

该项目旨在确定人体如何防御与蛋白质折叠相关的疾病和生活质量下降。暴露在日常物理和化学压力下会导致蛋白质失去正常形状并错误折叠。错误折叠的蛋白质与人类衰老和严重疾病(例如阿尔茨海默病)有因果关系。然而，人体确实有一个保护系统，可以从体液中清除危险的错误折叠的蛋白质。使用尖端方法和一种新的动物模型，该项目旨在建立这个系统是如何工作的。这些成果预计将增进对影响人类老龄化和疾病的分子过程的理解，并加强制定更好的战略来应对这些问题所需的框架。