The effects of alpha-2-macroglobulin on amyloid formation and toxicity

预期的结果将在理解丰富的人类血液蛋白α-2-巨球蛋白如何影响蛋白质聚集体的形成方面取得重大进展，这些蛋白质聚集体是许多严重疾病（例如阿尔茨海默病）的基础。所涉及的联系是最高水平的，将使研究金保持器获得者有独特的机会在真正国际领先的环境中接受培训。此外，这项工作的高度新奇和广泛意义表明，它将产生高影响力的出版物，这将切实有助于澳大利亚被公认为最高质量国际研究成果的主要贡献者。

The expected outcomes will provide major advances in understanding how the abundant human blood protein alpha-2-macroglobulin influences the formation of protein aggregates that underpin a number of serious diseases (e.g. Alzheimer's disease). The linkages involved are of the highest calibre and will give the Fellowship holder a unique opportunity for training in environments that are truly internationally leading-edge. Furthermore, the very high novelty and broad significance of this work indicate that it will produce high-impact publications which will tangibly assist Australia being recognized as a major contributor to international research outcomes of the highest quality.