CRC: Collaborative Research: Chemistry of Microbially-Produced Biosurfactants

CRC：合作研究：微生物生产的生物表面活性剂的化学

• 批准号: 0714245
• 负责人: Jeanne Pemberton
• 金额: $ 276万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0714245&HistoricalAwards=false
• 关键词: CRC; Collaborative; Research; Chemistry; Microbially

Jeanne Pemberton, Raina Maier, Robin Polt, Maria-Teresa Velez, Robert Bates (University of Arizona) and Jani Ingram (Northern Arizona University) are jointly supported to study the fundamental surface and interfacial chemistry of biosurfactants, particularly the rhamnolipids, siderolipids, surfactins and sophorolipids. Synthetic analogues to the microbially-produced biosurfactants will also be studied. The project will incorporate chemical synthesis, surface and interface analysis, theory and modeling, as well as a microbiology component to study the biosynthetic pathways and molecular environments that influence which biosurfactants are made under what conditions. Biosurfactants are known to aggregate in solution at low concentrations and exhibit powerful surfactant activity at both liquid and solid surfaces. Each individual biosurfactant can have remarkably different properties, because their interactions are driven by the interplay of van der Waals forces, dipole-dipole interactions, and solvation effects. Biosurfactants will be characterized in solution using light scattering, the vibrational spectroscopies, NMR spectroscopy, mass spectrometry and surface tension measurements, while biosurfactant assemblies at interfaces and on surfaces will be characterized using a combination of the vibrational spectroscopies and atomic force microscopy.This project is funded through the Collaborative Research in Chemistry Program (CRC) and the Office of Multidisciplinary Activities in the Directorate for Mathematical and Physical Sciences. Biosurfactants have potential applications in industrial, medical, pharmaceutical and environmental applications. This interdisciplinary research project will be used as a platform to improve the recruitment and participation of underrepresented students, especially Hispanics and Native Americans, in scientific careers in chemistry and environmental science. This award provides collaborative training and research opportunities for K-12 teachers and students, and undergraduate and graduate students at both institutions.

Jeanne Pemberton、Raina Maier、Robin Polt、Maria-Teresa Velez、Robert Bates（亚利桑那大学）和 Jani Ingram（北亚利桑那大学）共同支持研究生物表面活性剂的基础表面和界面化学，特别是鼠李糖脂、铁脂、表面活性素和槐糖脂。微生物产生的生物表面活性剂的合成类似物也将被研究。该项目将结合化学合成、表面和界面分析、理论和建模以及微生物学部分，以研究影响生物表面活性剂在何种条件下制造的生物合成途径和分子环境。已知生物表面活性剂在低浓度的溶液中聚集，并在液体和固体表面表现出强大的表面活性剂活性。每种生物表面活性剂都可以具有显着不同的特性，因为它们的相互作用是由范德华力、偶极-偶极相互作用和溶剂化效应的相互作用驱动的。将使用光散射、振动光谱、核磁共振光谱、质谱和表面张力测量来表征溶液中的​​生物表面活性剂，而界面和表面上的生物表面活性剂组件将使用振动光谱和原子力显微镜的组合来表征。该项目由化学合作研究计划（CRC）和办公室资助 数学和物理科学理事会的多学科活动。生物表面活性剂在工业、医疗、制药和环境应用中具有潜在的应用。 这个跨学科研究项目将用作一个平台，以改善代表性不足的学生，特别是西班牙裔和美洲原住民在化学和环境科学科学职业中的招募和参与。该奖项为两个机构的 K-12 教师和学生以及本科生和研究生提供协作培训和研究机会。