CRC: Collaborative Research: Chemistry of Microbially-Produced Biosurfactants

CRC：合作研究：微生物生产的生物表面活性剂的化学

• 批准号: 0714245
• 负责人: Jeanne Pemberton
• 金额: $ 276万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0714245&HistoricalAwards=false
• 关键词: CRC; Collaborative; Research; Chemistry; Microbially

Jeanne Pemberton, Raina Maier, Robin Polt, Maria-Teresa Velez, Robert Bates (University of Arizona) and Jani Ingram (Northern Arizona University) are jointly supported to study the fundamental surface and interfacial chemistry of biosurfactants, particularly the rhamnolipids, siderolipids, surfactins and sophorolipids. Synthetic analogues to the microbially-produced biosurfactants will also be studied. The project will incorporate chemical synthesis, surface and interface analysis, theory and modeling, as well as a microbiology component to study the biosynthetic pathways and molecular environments that influence which biosurfactants are made under what conditions. Biosurfactants are known to aggregate in solution at low concentrations and exhibit powerful surfactant activity at both liquid and solid surfaces. Each individual biosurfactant can have remarkably different properties, because their interactions are driven by the interplay of van der Waals forces, dipole-dipole interactions, and solvation effects. Biosurfactants will be characterized in solution using light scattering, the vibrational spectroscopies, NMR spectroscopy, mass spectrometry and surface tension measurements, while biosurfactant assemblies at interfaces and on surfaces will be characterized using a combination of the vibrational spectroscopies and atomic force microscopy.This project is funded through the Collaborative Research in Chemistry Program (CRC) and the Office of Multidisciplinary Activities in the Directorate for Mathematical and Physical Sciences. Biosurfactants have potential applications in industrial, medical, pharmaceutical and environmental applications. This interdisciplinary research project will be used as a platform to improve the recruitment and participation of underrepresented students, especially Hispanics and Native Americans, in scientific careers in chemistry and environmental science. This award provides collaborative training and research opportunities for K-12 teachers and students, and undergraduate and graduate students at both institutions.

Jeanne Pemberton，Raina Maier，Robin Polt，Maria-Teresa Velez，Robert Bates（亚利桑那大学）和Jani Ingram（北亚利桑那大学）共同支持研究生物表面和生物外部化学的基本表面和互面部化学，特别是rhamnolipids，Siderolipids，serorolipids，soporipicts，soprofactids，sophorfactids and Sophorfactids。还将研究对微生物生产的生物表面活性剂的合成类似物。该项目将结合化学合成，表面和界面分析，理论和建模，以及研究生物合成途径和分子环境的微生物学成分，这些途径和分子环境会影响哪种生物表面活性剂在什么条件下制造的生物表面活性剂。已知生物表面活性剂在低浓度下在溶液中聚集，并在液体和固体表面都表现出强大的表面活性剂活性。每个单独的生物表面活性剂都可以具有明显不同的特性，因为它们的相互作用是由范德华力，偶极 - 偶极相互作用和溶剂化作用的相互作用驱动的。生物表面活性剂将在使用光散射，振动光谱，NMR光谱法，质谱和表面张力测量的溶液中进行表征，而在互动和表面上的生物表面活性剂组件将通过振动谱和振动仪的组合来表征。数学和物理科学局的多学科活动。生物表面活性剂在工业，医疗，药物和环境应用中有潜在的应用。 该跨学科研究项目将被用作一个平台，以改善代表性不足的学生，尤其是西班牙裔和美洲原住民的招聘和参与，从事化学和环境科学领域的科学职业。该奖项为K-12教师和学生以及两个机构的本科生和研究生提供了合作培训和研究机会。