Development of s-Block Organometallic Reagents

s-Block有机金属试剂的开发

• 批准号: 0717593
• 负责人: Kenneth Henderson
• 金额: $ 38.3万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0717593&HistoricalAwards=false
• 关键词: Development; Block; Organometallic; Reagents

The project is directed towards realizing the potential of s-block organometallic complexes as reagents in organic synthesis. The goal of the project is to exploit the utility of these metals in the efficient preparation of organic molecules that are of practical value to synthetic chemists. Three specific areas of study will be focused upon: (i) developing alkaline earth metal reagents to mediate enantioselective deprotonation reactions, (ii) exploring the synthesis and synthetic utility of alkaline earth chargeseparated complexes, and (iii) examining the preparation and functionality of geminal diorganometallic complexes. The strategies adopted will uncover fundamental aspects concerning the synthesis, structures, reactivities, selectivities and mechanisms of action of the reagents developed. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Kenneth W. Henderson, of the Department of Chemistry and Biochemistry at the University of Notre Dame. The main goal of the project is to develop new methods and reagents for synthetic organic chemistry, exploiting the unusual reactivity of the heavier congeners (e.g., calcium) of the more commonly encountered lithium- and magnesium-containing reagents. In turn, the developed methods may be applied to the synthesis of biologically active compounds for use in areas of central importance to the US economy such as the agrochemical and pharmaceutical industries. In addition, the metals of interest are generally inexpensive, nontoxic and environmentally benign, which makes their use attractive in industrial settings.

该项目旨在实现s-区有机金属配合物作为有机合成试剂的潜力。该项目的目标是利用这些金属有效制备对合成化学家具有实用价值的有机分子。三个具体的研究领域将集中在：（一）开发碱土金属试剂介导的对映选择性去质子化反应，（二）探索合成和碱土电荷分离配合物的合成效用，及（三）研究的准备和功能的偕diorganometallic配合物。所采用的策略将揭示有关的合成，结构，反应性，选择性和开发的试剂的作用机制的基本方面。有了这个更新奖，有机和高分子化学计划是支持教授肯尼思W。圣母大学化学和生物化学系的亨德森说。该项目的主要目标是开发用于合成有机化学的新方法和试剂，利用较重同系物的不寻常反应性（例如，钙）更常见的含锂和镁试剂。反过来，所开发的方法可以应用于合成生物活性化合物，用于对美国经济至关重要的领域，例如农用化学品和制药工业。此外，感兴趣的金属通常是廉价的、无毒的和环境友好的，这使得它们在工业环境中的使用具有吸引力。