Development of s-Block Organometallic Reagents

该项目旨在实现S嵌段有机金属配合物在有机合成中作为试剂的潜力。该项目的目标是利用这些金属有效地制备对合成化学家有实用价值的有机分子。将集中于三个具体的研究领域：(I)开发碱土金属试剂来催化不对称去质子化反应，(Ii)探索碱土电荷分离络合物的合成和合成用途，以及(Iii)研究双金属双有机金属络合物的制备和功能。所采用的策略将揭示有关所开发试剂的合成、结构、反应性、选择性和作用机理的基本方面。通过这一续展奖项，有机和高分子化学项目支持圣母大学化学和生物化学系的Kenneth W.Henderson教授的研究。该项目的主要目标是开发合成有机化学的新方法和试剂，利用更常见的锂和镁试剂中较重的同系物(如钙)的不同寻常的反应性。反过来，开发的方法可以用于合成生物活性化合物，用于对美国经济至关重要的领域，如农化和制药工业。此外，感兴趣的金属通常价格低廉、无毒和对环境无害，这使得它们在工业环境中的使用具有吸引力。

The project is directed towards realizing the potential of s-block organometallic complexes as reagents in organic synthesis. The goal of the project is to exploit the utility of these metals in the efficient preparation of organic molecules that are of practical value to synthetic chemists. Three specific areas of study will be focused upon: (i) developing alkaline earth metal reagents to mediate enantioselective deprotonation reactions, (ii) exploring the synthesis and synthetic utility of alkaline earth chargeseparated complexes, and (iii) examining the preparation and functionality of geminal diorganometallic complexes. The strategies adopted will uncover fundamental aspects concerning the synthesis, structures, reactivities, selectivities and mechanisms of action of the reagents developed. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Kenneth W. Henderson, of the Department of Chemistry and Biochemistry at the University of Notre Dame. The main goal of the project is to develop new methods and reagents for synthetic organic chemistry, exploiting the unusual reactivity of the heavier congeners (e.g., calcium) of the more commonly encountered lithium- and magnesium-containing reagents. In turn, the developed methods may be applied to the synthesis of biologically active compounds for use in areas of central importance to the US economy such as the agrochemical and pharmaceutical industries. In addition, the metals of interest are generally inexpensive, nontoxic and environmentally benign, which makes their use attractive in industrial settings.