Development of Novel s-Block Organometallic Reagents

本研究计划将建立一系列第二族有机金属化合物作为试剂的广泛应用，以进行各种重要的合成有机转化。铋胺镁可作为对映选择性去质子化反应的选择性碱。在对映选择性还原和不对称wittig型反应中，镁试剂会对烯醇阴离子加成反应和羰基加成反应产生不对称诱导。还将研究同手性较重的2族类似物（Ca, Ba, Sr）的相关化学性质。反应性研究将辅以结构和理论分析。通过这个新奖项，有机和分子化学项目支持了圣母大学化学和生物化学系的Kenneth W. Henderson教授的工作。亨德森教授正在研究含有镁、钙、钡和锶的特殊化合物的合成、结构和反应性。这些化合物为实现高选择性有机化学转化提供了希望，同时提供了许多比传统试剂更实用的优势，包括低毒、低成本和有效的功能，而不需要专门的反应条件。

This research program will establish the broad-based utility of a series of group 2 organometallic compounds as reagents to perform a variety of synthetically important organic transformations. Magnesium bisamides will be developed as selective bases for enantioselective deprotonation reactions. Magnesium reagents will be explored which effect asymmetric induction in addition reactions to enolate anions and across carbonyls, in enantioselective reductions, and in asymmetric Wittig-type reactions. The related chemistry of homochiral heavier group 2 analogs (Ca, Ba, Sr) will also be studied. Reactivity studies will be complemented with structural and theoretical analyses.With this new award, the Organic and Macomolecular Chemistry Program is supporting the work of Professor Kenneth W. Henderson, of the Department of Chemistry and Biochemistry at the University of Notre Dame. Professor Henderson is exploring the synthesis, structure, and reactivity of unusual compounds containing magnesium, calcium, barium, and strontium. These compounds offer promise for effecting highly selective organic chemical transformations while providing a number of practical advantages over more traditional reagents, including low toxicity, low cost, and effective function without the need for specialzied reaction conditions.