Interactions Between MADS-Domain Floral Repressors in the Photoperiod Pathway

MADS 域花抑制因子在光周期途径中的相互作用

• 批准号: 0718598
• 负责人: Donna Fernandez
• 金额: --
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0718598&HistoricalAwards=false
• 关键词: Interactions; Between; MADS; Domain; Floral

Donna E. FernandezProposal No. IOS-0718598Title: Interactions between MADS-domain floral repressors in the photoperiod pathway.The time at which a plant flowers depends both on external factors, such as light and temperature, and internal factors, such as the age and condition of the plant. Information about these factors is fed into a complex network of positively- and negatively-acting molecular regulators, which control the switch from formation of leaves to formation of flowers. The MADS-domain proteins AGAMOUS-LIKE15, AGAMOUS-LIKE18, and SHORT VEGETATIVE PHASE (SVP) have been identified as negatively-acting regulators in this network through genetic analyses in Arabidopsis. Genetic and molecular studies will be performed to define how these factors contribute, both individually and collectively, to the regulatory network. This work will give insight into the nature of regulatory complexes that control flowering, their mechanism of action, and interactions between them. These insights will add to the understanding of the molecular basis for control of developmental processes, with potential implications in many areas ranging from reproductive biology to disease development and crop yield. The project will provide training opportunities for several young scientists at the undergraduate and graduate level.

唐娜·E·费尔南德斯提案编号：IOS-0718598标题：光周期途径中MADS结构域的花抑制因子之间的相互作用。植物开花的时间既取决于外部因素，如光和温度，也取决于内部因素，如植物的年龄和状况。有关这些因素的信息被输入到一个由正负作用的分子调节器组成的复杂网络中，这些分子调节器控制着从叶片形成到花形成的开关。通过对拟南芥的遗传分析，已经确定MADS结构域蛋白AGAMOUS-LIKE15、AGAMOUS-LIKE18和短营养阶段(SVP)是该网络中负作用的调节因子。将进行遗传和分子研究，以确定这些因素如何单独和共同对调控网络做出贡献。这项工作将深入了解控制开花的调控复合体的性质，它们的作用机制，以及它们之间的相互作用。这些见解将增加对控制发育过程的分子基础的理解，在从生殖生物学到疾病发展和作物产量的许多领域都有潜在的影响。该项目将为几名本科生和研究生提供培训机会。