Development of fluorescent probes-dendrimer conjugates and their application for cell and in vivo imaging

在这项研究中，我们发现在BODIPY中引入氨基后，其吸收光谱和荧光光谱发生了显著的变化，并基于这一发现，成功地开发了几种荧光探针。此外，我们还合成了BDOIPY和Frechet型树枝状大分子的共轭化合物，用于荧光成像应用。此外，我们还发现，一些具有近红外发射的稀土发光配合物可以被引入到活细胞中，这取决于它们的天线部分的结构。

In this study, we discovered that introduction of amino groups to BODIPY resulted in remarkable alternation of its absorption and fluorescence spectra, and based on this finding, succeeded in the development of several fluorescent probes. Furthermore, we synthesized conjugates of BDOIPYs and Frechet type dendrimers for fluorescence imaging applications. Also, we found that some luminescent lanthanide complexes with near-infrared emission could be introduced to live cells, depending on the structure of their antenna moiety.