CSR-CSI: Software Environment for Real-Time Non-Rigid Registration using Commodity and Grid Computing

在这个项目中，我们将关注在网格上执行多个并行非刚性注册的端到端软件环境的四个重要方面（需求）。我们的应用是图像引导神经外科（igs）。神经外科切除术是恶性脑肿瘤治疗中常用的治疗干预手段，是神经外科手术切除的重要工具。在这个项目中我们将研究的四个需求是：(1)通过动态平衡处理器的工作负载，实现并行和分布式非刚性注册代码的高性能；(2)通过为我们的web服务客户端开发图形用户界面（GUI），使医生（放射科医生）易于使用web服务；(3)代码的可移植性，可以从单个高端工作站运行到本地和广域网内的多个工作站集群(4)可靠性，通过保证部分系统将完成图像配准的计算，并通过在运行时获取和重新配置系统来确保我们满足时间限制，以补偿丢失（故障）的计算资源。最终产品将是一个网络服务的原型。然而，该项目将对图像引导治疗产生更广泛的影响，因为相同的框架（但不同的模式和有限元近似模型）可用于前列腺活检和治疗，以及肝脏冷冻治疗。

In this project we will focus on four important aspects (requirements)of an end-to-end software environment for performing multiple parallelnon-rigid registrations over the Grid. Our application is Image GuidedNeurosurgery (IGNS). IGNS is an important tool for neurosurgicalresection which is a common therapeutic intervention in the treatmentof malignant brain tumors.The four requirements we will study in this project are: (1) thehigh-performance of the parallel and distributed non-rigidregistration code by dynamically balancing the processors work-load,(2) the ease-of-use from medical doctors (radiologist) of aweb-service by developing a Graphical User Interface (GUI) for clientsof our web-service (3) the portability of the code to run from asingle high-end workstation to more than one clusters of workstationswithin the local and wide area networks available to researchhospitals and medical centers, (4) the reliability by guaranteeingthat part of the system will complete the computations for the imageregistration and by making sure we meet the time constrains byacquiring and re-configuring the system at runtime to compensate forlost (faulty) computing resources.The end-product will be a prototype of an IGNS web-service. However,this project will have broader impact to image guided therapy becausethe same framework (but different modalities and finite elementapproximation models) can be used in prostate biopsy and treatment,and liver cryotherapy.