Steroidal Regulation of Synaptic Input in the MPN mag

MPN mag 中突触输入的类固醇调节

• 批准号: 0721462
• 负责人: Jennifer Swann
• 金额: $ 44万
• 依托单位: Lehigh University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0721462&HistoricalAwards=false
• 关键词: Steroidal; Regulation; Synaptic; Input; MPN

Steroids exert dramatic, highly reproducible effects on behavior in every species studied to date from insects to man. Behavioral changes are strongly correlated with structural and functional changes in the connections among the cells in the brain, or synapses in the adult brain. Gonadal steroids such as testosterone have been shown to accelerate and induce changes in the strength and number of synapses in areas responsible for learning and memory. The goal of this project is to determine if the presence or absence of testosterone changes synaptic strength among nerve cells in a neural network responsible for social and reproductive behaviors in adults. Synapses will be identified with the latest technology and examined under low and high power microscopes to identify significant changes in the number, function, and source of synapses in the preoptic area, an important integrating structure in this network. Results from these studies will enhance our understanding of the role of gonadal steroids in the regulation of neural function in the adult brain, thus setting the stage for future studies of growth enhancing chemicals and substrates involved in sexual differentiation, aging and injury. This project will offer unique training opportunites in neuroanatomy and will include undergraduates and graduates in the collection, analysis and processing of the results.

类固醇对迄今为止所研究的从昆虫到人类的每一个物种的行为都产生了戏剧性的、高度重复性的影响。行为变化与大脑中细胞之间的连接或成人大脑中的突触的结构和功能变化密切相关。性腺类固醇，如睾酮，已被证明加速并诱导负责学习和记忆的区域中突触的强度和数量的变化。该项目的目标是确定睾酮的存在或不存在是否会改变负责成年人社会和生殖行为的神经网络中神经细胞之间的突触强度。突触将用最新的技术进行识别，并在低倍和高倍显微镜下进行检查，以确定视前区突触的数量、功能和来源的显著变化，视前区是该网络中重要的整合结构。这些研究的结果将加深我们对性腺类固醇在成人大脑神经功能调节中的作用的理解，从而为未来涉及性别分化、衰老和损伤的生长促进化学物质和底物的研究奠定基础。该项目将在神经解剖学方面提供独特的培训机会，并将包括本科生和毕业生参与结果的收集、分析和处理。