Transcriptional Regulation by Arabidopsis LITTLE ZIPPER Proteins
拟南芥 LITTLE ZIPPER 蛋白的转录调控
基本信息
- 批准号:0721852
- 负责人:
- 金额:$ 44.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-10-01 至 2011-09-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Class III homeodomain-leucine zipper (HD-ZIPIII) transcription factors promote important morphological attributes such as vascular patterning, outgrowth of the leaf blade, meristem formation and meristem size in plants. This project investigates mechanism through which HD-ZIPIII protein activity is modulated, extending Dr. Barton's recent discoveries that a new family of small proteins called LITTLE ZIPPERs are regulated by HD-ZIPIIIs transcriptionally, and regulate the activities of HD-ZIPIIIs through a feedback loop. The hypothesis that LITTLE ZIPPERs heterodimerize with the HD-ZIPIII proteins to either inhibit or alter their ability to bind DNA will be tested to probe the mechanism through which the LITTLE ZIPPERs inhibit HD-ZIPIII function. The native target sites for HD-ZIPIII binding in Arabidopsis LITTLE ZIPPER promoters will be identified. The consequence to the plant of loss of LITTLE ZIPPER activity will be determined. Finally, the binding of a hydrophobic ligand to the the HDZIPIII proteins is hypothesized and such ligands will be identified by screening a small chemical library. This project will directly widen our understanding of the regulation of plant development. Practical outcomes of this work include the ability to engineer desirable regulatory circuits and the potential to create plant varieties with desirable morphological features for the improvement of food and energy crops.The project will have a significant impact on K-12 and undergraduate education. The lab will train postdoctoral researchers, undergraduate and high school students in modern plant biology research.
III类同源结构域-亮氨酸拉链(HD-ZIPIII)转录因子促进植物中重要的形态学属性,例如维管图案化、叶片的生长、分生组织形成和分生组织大小。该项目研究了HD-ZIPIII蛋白活性调节的机制,扩展了巴顿博士最近的发现,即一个名为LITTLE ZIPPERs的新小蛋白家族在转录上受到HD-ZIPIII的调节,并通过反馈回路调节HD-ZIPIII的活性。 将测试LITTLE ZIPPERs与HD-ZIPIII蛋白异二聚化以抑制或改变其结合DNA的能力的假设,以探索LITTLE ZIPPERs抑制HD-ZIPIII功能的机制。 将鉴定拟南芥LITTLE ZIPPER启动子中HD-ZIPIII结合的天然靶位点。将确定LITTLE ZIPPER活性丧失对电厂造成的后果。最后,假设疏水配体与HDZIPIII蛋白的结合,并且将通过筛选小的化学文库来鉴定这样的配体。这个项目将直接拓宽我们对植物发育规律的理解。这项工作的实际成果包括能够设计出理想的调节回路,并有可能创造出具有理想形态特征的植物品种,以改善粮食和能源作物。该项目将对K-12和本科教育产生重大影响。该实验室将培养现代植物生物学研究的博士后研究人员,本科生和高中生。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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M. Kathryn Barton其他文献
The Ins and Outs of <em>Arabidopsis</em> Embryogenesis
- DOI:
10.1016/j.devcel.2007.05.010 - 发表时间:
2007-06-05 - 期刊:
- 影响因子:
- 作者:
M. Kathryn Barton - 通讯作者:
M. Kathryn Barton
M. Kathryn Barton的其他文献
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{{ truncateString('M. Kathryn Barton', 18)}}的其他基金
Meeting: Workshop on Plant Development and Drought Stress, to be held November 5-8, 2017 at Asilomar Conference Grounds in Pacific Grove, CA.
会议:植物发育和干旱胁迫研讨会,将于 2017 年 11 月 5 日至 8 日在加利福尼亚州太平洋丛林的阿西洛玛会议场地举行。
- 批准号:
1747902 - 财政年份:2017
- 资助金额:
$ 44.97万 - 项目类别:
Standard Grant
Meeting: Workshop on Plant Development and Drought Stress, to be held November 1-4, 2015 at Asilomar Conference Grounds in Pacific Grove, CA.
会议:植物发育和干旱胁迫研讨会,将于 2015 年 11 月 1 日至 4 日在加利福尼亚州太平洋丛林的阿西洛玛会议场地举行。
- 批准号:
1550808 - 财政年份:2015
- 资助金额:
$ 44.97万 - 项目类别:
Standard Grant
Arabidopsis 2010: The ad/abaxial regulatory network of Arabidopsis
拟南芥 2010:拟南芥的上轴/远轴调控网络
- 批准号:
0929413 - 财政年份:2010
- 资助金额:
$ 44.97万 - 项目类别:
Continuing Grant
Molecular Genetic Analysis of Shoot Apical Meristem Development in Arabidopsis thaliana
拟南芥茎尖分生组织发育的分子遗传学分析
- 批准号:
0296068 - 财政年份:2001
- 资助金额:
$ 44.97万 - 项目类别:
Continuing Grant
Molecular Genetic Analysis of Shoot Apical Meristem Development in Arabidopsis thaliana
拟南芥茎尖分生组织发育的分子遗传学分析
- 批准号:
0080853 - 财政年份:2000
- 资助金额:
$ 44.97万 - 项目类别:
Continuing Grant
Investigating the Link Between Growth and Pattern in the Arabidopsis Embryo
研究拟南芥胚胎生长与模式之间的联系
- 批准号:
9973579 - 财政年份:1999
- 资助金额:
$ 44.97万 - 项目类别:
Standard Grant
Molecular Genetic Analysis of Shoot Apical Meristem Development in Arabidopsis Thaliana
拟南芥茎尖分生组织发育的分子遗传学分析
- 批准号:
9724163 - 财政年份:1997
- 资助金额:
$ 44.97万 - 项目类别:
Continuing Grant
Molecular Genetic Analysis of Shoot Apical Meristem Development in Arabidopsis Thaliana
拟南芥茎尖分生组织发育的分子遗传学分析
- 批准号:
9408731 - 财政年份:1994
- 资助金额:
$ 44.97万 - 项目类别:
Continuing Grant
Cloning the Shootless Locus of Arabidopsis Thaliana
克隆拟南芥无芽基因座
- 批准号:
9222013 - 财政年份:1992
- 资助金额:
$ 44.97万 - 项目类别:
Standard Grant
Postdoctoral Research Fellowship in Plant Biology
植物生物学博士后研究奖学金
- 批准号:
8906070 - 财政年份:1989
- 资助金额:
$ 44.97万 - 项目类别:
Fellowship Award
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