The role of nitric oxide in modulating the hypoxic tumor response

一氧化氮在调节缺氧肿瘤反应中的作用

• 批准号: 183242546
• 负责人: Professor Dr. Joachim Fandrey
• 金额: --
• 依托单位: Institut für Physiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/183242546?language=en
• 关键词: role; nitric; oxide; modulating; hypoxic

Tumor cells respond to hypoxia by activating hypoxia-inducible factor 1 (HIF-1), which controls metabolic adaptation, angiogenesis, and metastasis. Invading macrophages from the stroma of the host communicate with the tumor by releasing nitric oxide. We have found that nitric oxide can modulate the cellular oxygen-sensing process that controls HIF-1–dependent hypoxic gene activation. Understanding the mechanisms underlying this modulation would provide a deeper insight into the communication between tumor and host and would provide the basis for targeting the mechanisms by which tumor cells survive hypoxia and spread.

肿瘤细胞通过激活低氧诱导因子1（HIF-1）对低氧作出反应，HIF-1控制代谢适应、血管生成和转移。从宿主间质侵入的巨噬细胞通过释放一氧化氮与肿瘤沟通。我们已经发现，一氧化氮可以调节细胞的氧敏感过程，控制HIF-1依赖的缺氧基因激活。了解这种调节的机制将为肿瘤和宿主之间的沟通提供更深入的了解，并为靶向肿瘤细胞在缺氧和扩散中存活的机制提供基础。

项目成果

Rocket fuel for the quantification of S-nitrosothiols. Highly specific reduction of S-nitrosothiols to thiols by methylhydrazine

用于定量 S-亚硝基硫醇的火箭燃料 通过甲基肼将 S-亚硝基硫醇高度特异性地还原为硫醇

• DOI: 10.3109/10715762.2012.744836
• 发表时间: 2013
• 期刊: Free Radical Research
• 影响因子: 3.3
• 作者: Wiesweg M;Berchner-Pfannschmidt U;Fandrey J;Petrat F;de Groot H;Kirsch M
• 通讯作者: Kirsch M

Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling

• DOI: 10.1242/jcs.109041
• 发表时间: 2012-11-01
• 期刊: JOURNAL OF CELL SCIENCE
• 影响因子: 4
• 作者: Pientka, Friederike Katharina;Hu, Jun;Depping, Reinhard
• 通讯作者: Depping, Reinhard

Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia

• DOI: 10.3109/10715762.2012.669041
• 发表时间: 2012-06-01
• 期刊: FREE RADICAL RESEARCH
• 影响因子: 3.3
• 作者: Niecknig, Helene;Tug, Suzan;Berchner-Pfannschmidt, Utta
• 通讯作者: Berchner-Pfannschmidt, Utta