MRI: Acquisition of an advanced micro-Computed Tomography imaging facility

CBET-0723027卡多佐这份提案描述了纽约城市学院(CCNY)的一个多用户先进成像设施。它包括一个微焦点X射线计算机层析成像(Micro-CT)扫描系统、一个用于图像采集的专用服务器和四个用于重建、处理和分析三维数据的工作站。该成像设施将为CCNY格罗夫工程学院(GSOE)的五个工程系中的四个、生物医学工程(BME)、机械工程(ME)、化学工程(CHE)和电气工程(EE)以及纽约市主要医学研究机构的研究伙伴提供服务。本提案所要求的微型CT扫描仪和采集系统将设在生物医学工程系生物力学实验室内。这个空间位于CCNY的格罗夫工程学院内，因此为所有用户提供了方便的通道。高分辨率微型计算机断层成像是一项最近的技术，它彻底改变了材料和组织的无损评估。它为可视化由不同密度的物质组成的复杂结构提供了独特的手段。特别是，它可以分析高密度组织(骨、钙化动脉、肿瘤等)和充满高密度造影剂的结构。由于其惊人的高灵敏度，它还可以生成软组织、脂肪和血管内空气的详细3D图像。与传统组织学处理相关的几个缺点，如渗透、脱水和连续切片，微CT可以避免。虚拟的非破坏性组织学可以快速地作为一堆连续的图像(横截面)获得，每个图像的厚度为几微米。此外，对几个组织形态计量学特征的分析是自动的，减少了测量误差，并允许构建复杂的数值模型。

CBET-0723027 Cardoso This proposal describes a multi-user advanced imaging facility at The City College of New York (CCNY). It comprises a microfocus X-Ray Computed Tomography (micro-CT) scanning system, a dedicated server for images acquisition and four workstations for reconstruction, treatment and analysis of 3-D data. The imaging facility will provide service to four of the five engineering departments in the Grove School of Engineering (GSOE) at CCNY, Biomedical Engineering (BME), Mechanical Engineering (ME), Chemical Engineering (ChE) and Electrical Engineering (EE) and research partners at major medical research institutions in New York City. The micro-CT scanner and acquisition system requested in this proposal will be housed within the Biomechanics Laboratory in the Department of Biomedical Engineering. This space is located within the Grove School of Engineering at CCNY, thus providing convenient access to all the users. High resolution micro-Computed Tomography is a recent technology that has revolutionized the nondestructive assessment of materials and tissues. It provides a unique means for visualization of complex structures composed by substances with different densities. In particular, it permits the analysis of high-density tissues (bone, calcified arteries, neoplasias, etc) and structures filled with high-density contrast agents. It also produces detailed 3-D images of soft tissue, lipid, and air within blood vessels due to its remarkable high sensitivity. Several disadvantages associated with classical histological processing of tissue, such as infiltration, dehydration and serial sectioning is avoided with micro-CT. Virtual nondestructive histology is rapidly obtained as a stack of consecutive images (cross sections) with each image a few microns in thickness. Moreover, the analysis of several histomorphometric features is automatic, reducing measurement errors, and permitting construction of complex numerical models.