MRI: Acquisition of an advanced micro-Computed Tomography imaging facility

MRI：购置先进的微型计算机断层扫描成像设备

• 批准号: 0723027
• 负责人: Luis Cardoso
• 金额: $ 33.95万
• 依托单位: CUNY City College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0723027&HistoricalAwards=false
• 关键词: MRI; Acquisition; advanced; micro; Computed

CBET-0723027 Cardoso This proposal describes a multi-user advanced imaging facility at The City College of New York (CCNY). It comprises a microfocus X-Ray Computed Tomography (micro-CT) scanning system, a dedicated server for images acquisition and four workstations for reconstruction, treatment and analysis of 3-D data. The imaging facility will provide service to four of the five engineering departments in the Grove School of Engineering (GSOE) at CCNY, Biomedical Engineering (BME), Mechanical Engineering (ME), Chemical Engineering (ChE) and Electrical Engineering (EE) and research partners at major medical research institutions in New York City. The micro-CT scanner and acquisition system requested in this proposal will be housed within the Biomechanics Laboratory in the Department of Biomedical Engineering. This space is located within the Grove School of Engineering at CCNY, thus providing convenient access to all the users. High resolution micro-Computed Tomography is a recent technology that has revolutionized the nondestructive assessment of materials and tissues. It provides a unique means for visualization of complex structures composed by substances with different densities. In particular, it permits the analysis of high-density tissues (bone, calcified arteries, neoplasias, etc) and structures filled with high-density contrast agents. It also produces detailed 3-D images of soft tissue, lipid, and air within blood vessels due to its remarkable high sensitivity. Several disadvantages associated with classical histological processing of tissue, such as infiltration, dehydration and serial sectioning is avoided with micro-CT. Virtual nondestructive histology is rapidly obtained as a stack of consecutive images (cross sections) with each image a few microns in thickness. Moreover, the analysis of several histomorphometric features is automatic, reducing measurement errors, and permitting construction of complex numerical models.

CBET-0723027 Cardoso 该提案描述了纽约城市学院 (CCNY) 的多用户高级成像设施。它包括一个微焦点 X 射线计算机断层扫描 (micro-CT) 扫描系统、一个用于图像采集的专用服务器以及四个用于重建、处理和分析 3D 数据的工作站。该成像设施将为 CCNY 格罗夫工程学院 (GSOE) 五个工程系中的四个、生物医学工程 (BME)、机械工程 (ME)、化学工程 (ChE) 和电气工程 (EE) 以及纽约市主要医学研究机构的研究合作伙伴提供服务。本提案中要求的微型 CT 扫描仪和采集系统将安置在生物医学工程系的生物力学实验室内。该空间位于 CCNY 格罗夫工程学院内，为所有用户提供方便的访问。高分辨率微型计算机断层扫描是一项最新技术，彻底改变了材料和组织的无损评估。它提供了一种独特的方法来可视化由不同密度的物质组成的复杂结构。特别是，它可以分析高密度组织（骨、钙化动脉、肿瘤等）和填充有高密度造影剂的结构。由于其极高的灵敏度，它还能生成血管内软组织、脂质和空气的详细 3D 图像。显微 CT 避免了与组织的经典组织学处理相关的几个缺点，例如浸润、脱水和连续切片。虚拟无损组织学可快速获得一堆连续图像（横截面），每个图像的厚度为几微米。此外，几个组织形态特征的分析是自动的，减少了测量误差，并允许构建复杂的数值模型。