SBIR Phase II: Spatially-Resolved Swept-Laser Spectroscopic System for Gold Nanoparticle Sensing

SBIR 第二阶段：用于金纳米粒子传感的空间分辨扫频激光光谱系统

• 批准号: 0724231
• 负责人: Kevin Hsu
• 金额: $ 49.99万
• 依托单位: MICRON OPTICS INC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-11-15 至 2011-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0724231&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Spatially; Resolved

This Small Business Innovation Research (SBIR) Phase II project is to develop a spatially-resolved bio-sensing technology based on spectroscopic swept-source optical coherence tomography (S-SSOCT) and gold nanoparticles as bio-sensors at 1060nm spectral region. The proposed system will advance contrast-enhanced molecular imaging of diseased tissue. The project will explore several contrasting agents for imaging applications, among these are; the traditional florescence and absorption dyes, to the latest semiconductor quantum dots and metallic nanoparticles. The recently engineered gold nanoparticles possess superior light scattering and absorbing characteristics as well as long-term stability, and when bound to antibodies, can enable high-contrast molecular and cellular imaging of various diseases. The advancement of biotechnology and nanotechnology will benefit greatly from the ability to perform spatially-resolved and sensitive imaging of diseases in molecular and cellular levels through contrast enhancing agents. One expected outcome of this project is to make it possible to track the effectiveness of pharmaceuticals, treat disease, monitor responses to therapies, as well as to provide novel pairing of therapeutic and diagnostic processes. A particular goal of this project is to advance cancer diagnostic technology by developing a high-speed, high-resolution bio-medical imaging modality using gold nanoparticle as bio-conjugated sensors. This market is driven by synergy between various imaging methods (optical, nuclear, and magnetic) and new types of imaging agents.

该小型企业创新研究 (SBIR) 第二阶段项目旨在开发一种基于光谱扫源光学相干断层扫描 (S-SSOCT) 和金纳米粒子作为 1060 nm 光谱区域生物传感器的空间分辨生物传感技术。所提出的系统将推进病变组织的对比增强分子成像。该项目将探索几种用于成像应用的造影剂，其中包括：从传统的荧光和吸收染料，到最新的半导体量子点和金属纳米颗粒。最近设计的金纳米颗粒具有优异的光散射和吸收特性以及长期稳定性，当与抗体结合时，可以实现各种疾病的高对比度分子和细胞成像。通过对比增强剂在分子和细胞水平上对疾病进行空间分辨和灵敏成像的能力将极大地受益于生物技术和纳米技术的进步。该项目的预期成果之一是能够跟踪药物的有效性、治疗疾病、监测治疗反应以及提供新颖的治疗和诊断过程配对。该项目的一个具体目标是通过开发使用金纳米颗粒作为生物共轭传感器的高速、高分辨率生物医学成像方式来推进癌症诊断技术。该市场是由各种成像方法（光学、核和磁）和新型成像剂之间的协同作用驱动的。