Lighting up the charged brigade: laser spectroscopy of protonated and metal-containing complexes

点亮充电旅：质子化和含金属配合物的激光光谱

• 批准号: DP0986980
• 负责人: Prof Evan Bieske
• 金额: $ 18万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0986980
• 关键词: Lighting; up; charged; brigade; laser

Increasingly, the design of new pharmaceuticals uses computer modeling to account for the shapes of molecules and how they interact with their surroundings. The strongest forces between molecular components are those that involve charged chemical species known as ions. In this project, we will develop advanced laser-based techniques to study in unprecedented detail how molecules respond to the presence of nearby charge, or to acquiring charge themselves. Understanding the nature of these attractions, and the structural changes that they induce eventually results in more accurate computer models. This has relevance to fields that include the architecture of proteins, recognition of signaling molecules in the brain, and drug development.

新药物的设计越来越多地使用计算机建模来解释分子的形状以及它们如何与周围环境相互作用。分子组分之间最强的力是那些带电的化学物质，即离子。在这个项目中，我们将开发先进的基于激光的技术，以前所未有的细节研究分子如何对附近电荷的存在做出反应，或者自己获取电荷。了解这些吸引力的本质，以及它们引起的结构变化，最终会产生更精确的计算机模型。这与蛋白质结构、大脑信号分子识别和药物开发等领域相关。