Shape-Shifting Molecules: Photoisomerization Action Spectroscopy

变形分子：光异构作用光谱

• 批准号: DP160100474
• 负责人: Prof Evan Bieske
• 金额: $ 47.43万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160100474
• 关键词: Shape; Shifting; Molecules; Photoisomerization; Action

This project aims to examine molecules that change shape in response to light in order to gain insight into the biological processes they control. Many biological systems, including the human visual apparatus and bacterial photosynthesis, depend on molecules that change shape in response to light. The project plans to probe shape-shifting molecules with laser light while they are propelled through gas by an electric field. Light-induced changes in molecular shape produce detectable variations in drift speed. The ensuing knowledge would help calibrate computational approaches for predicting molecular function. It would also establish foundations for understanding essential biological molecules, including retinals, carotenes and peptides, and for developing new light-activated molecular motors and switches.

该项目旨在研究响应光而改变形状的分子，以深入了解它们控制的生物过程。许多生物系统，包括人类的视觉器官和细菌的光合作用，都依赖于分子对光的响应而改变形状。该项目计划用激光探测在电场推动下通过气体的可变形分子。光诱导的分子形状变化产生可检测的漂移速度变化。随后的知识将有助于校准预测分子功能的计算方法。它还将为理解包括视黄醛、胡萝卜素和多肽在内的基本生物分子，以及开发新的光激活分子马达和开关奠定基础。