Design and Implementation of a Smart and Highly Efficient Magnetic Heating Scheme for Biomedical Applications

这项提案的目标是研究FeCo核/壳纳米粒子在几种生物医学应用中的应用，包括磁热治疗和药物输送。该项目在磁性纳米颗粒能量传输方面的主要贡献将通过：(1)由PI开发的具有更高饱和磁化强度的FeCo材料，(2)材料形貌的控制，以及(3)施加辅助磁场来定向颗粒。该项目的一个优点是在癌症应用中使用该技术来测试药物输送、热药物释放和核磁共振成像。研究计划包括对纳米颗粒的磁性、合成能力进行建模，以及制造各种表面可以化学修饰的生物相容外壳材料。与这个跨学科项目相关的重要教学部分将使想要了解研究的高中生和本科生以及开始研究生涯和合作教师的研究生受益。鼓励妇女和少数群体参与这项研究。这个跨学科项目将带来的最宝贵的经验是学术研究人员之间的合作氛围，他们之间的技能互补，共同工作。

0730825WangThe goal of this proposal is to investigate applications of FeCo core/shell nanoparticles for several biomedical applications, including magnetic hyperthermia and drug delivery. The major contribution of this project in the tenfold increase in the energy delivery of magnetic nanoparticles will be achieved through: (1) FeCo materials developed by the PI with a higher saturation magnetization, (2) control of the material morphology, and (3) application of a secondary magnetic field to orient the particles. A strength of this project is the use of the technology in a cancer application to test drug delivery, thermal drug release, and MRI imaging. The research plan includes modeling of the nanoparticle magnetic properties, synthesis capabilities, and fabrication of various biocompatible shell materials whose surfaces can be chemically modified. There are significant teaching components associated with this interdisciplinary project that will benefit high school and undergraduate students who want to learn about research and graduate students who begin their research career and collaborating faculties. Women and minority are encouraged to participate in this research. The most valuable experience that this interdisciplinary project will bring is the collaborative atmosphere among academic researchers with complementary skills to work together.