Design and Implementation of a Smart and Highly Efficient Magnetic Heating Scheme for Biomedical Applications

生物医学应用智能高效磁加热方案的设计与实现

• 批准号: 0730825
• 负责人: Jian-Ping Wang
• 金额: $ 27万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0730825&HistoricalAwards=false
• 关键词: Design; Implementation; Smart; Highly; Efficient

0730825WangThe goal of this proposal is to investigate applications of FeCo core/shell nanoparticles for several biomedical applications, including magnetic hyperthermia and drug delivery. The major contribution of this project in the tenfold increase in the energy delivery of magnetic nanoparticles will be achieved through: (1) FeCo materials developed by the PI with a higher saturation magnetization, (2) control of the material morphology, and (3) application of a secondary magnetic field to orient the particles. A strength of this project is the use of the technology in a cancer application to test drug delivery, thermal drug release, and MRI imaging. The research plan includes modeling of the nanoparticle magnetic properties, synthesis capabilities, and fabrication of various biocompatible shell materials whose surfaces can be chemically modified. There are significant teaching components associated with this interdisciplinary project that will benefit high school and undergraduate students who want to learn about research and graduate students who begin their research career and collaborating faculties. Women and minority are encouraged to participate in this research. The most valuable experience that this interdisciplinary project will bring is the collaborative atmosphere among academic researchers with complementary skills to work together.

该提案的目标是研究FeCo核/壳纳米颗粒在几种生物医学应用中的应用，包括磁热疗和药物递送。该项目的主要贡献是通过以下方式实现磁性纳米颗粒能量传输的十倍增长：（1）PI开发的具有更高饱和磁化强度的FeCo材料，（2）控制材料形态，以及（3）应用次级磁场来定向颗粒。 该项目的一个优势是在癌症应用中使用该技术来测试药物递送、热药物释放和MRI成像。 该研究计划包括纳米颗粒磁性的建模，合成能力，以及各种表面可以化学修饰的生物相容性外壳材料的制造。有与这个跨学科的项目，将有利于高中和本科生谁想要了解研究和研究生谁开始他们的研究生涯和合作院系相关的重要教学组件。鼓励妇女和少数民族参与这项研究。这个跨学科项目将带来的最有价值的经验是学术研究人员之间的合作氛围，他们具有互补的技能，可以一起工作。