Characterization and Model Development for the Cellular Response to Nanotube-Mediated Laser Therapy

细胞对纳米管介导的激光治疗反应的表征和模型开发

• 批准号: 0731108
• 负责人: Marissa Rylander
• 金额: $ 27万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0731108&HistoricalAwards=false
• 关键词: Characterization; Model; Development; Cellular; Response

0731108RylanderThe goal of the project is to characterize and model the thermal properties of carbon nanotubes (CNT) for delivering heat to cancer cells as a means to eradicate tumors. There are four specific aims: (1) measures of heat delivery, cell death and heat shock protein (HSP) expression for laser irradiated cells in solution with (CNT) carbon nanotubes (evaluations will consider the influence of tube structure, branching, dendritic formations and concentration), (2) determine temperature distributions in phantoms with CNT, (3) measure optical properties and thermal parameters associated with the tubes and their interaction with tissue, and (4) develop a computational model for predicting temperature distribution in tissue with CNT over the parametric range studied.The successful development of CNT assisted laser therapy could have substantial influence on the success of future treatments adopted for removing tumors and fighting cancer. As such, the investigation could have broad impact with tremendous value. The study will also evaluate the efficacy of these treatments in terms of both cell viability and HSP expression, which will address the potential for tissue recurrence. Also, the project also includes the development of a new course, establishing an outreach program for high school students, a mentoring seminar series for women in both undergraduate and graduate engineering programs.

0731108Rylander 该项目的目标是对碳纳米管 (CNT) 的热特性进行表征和建模，以向癌细胞传递热量，从而消除肿瘤。有四个具体目标：(1) 测量激光照射细胞在 (CNT) 碳纳米管溶液中的热传递、细胞死亡和热休克蛋白 (HSP) 表达（评估将考虑管结构、分支、树突形成和浓度的影响），(2) 确定 CNT 模型中的温度分布，(3) 测量与管相关的光学特性和热参数及其与管的相互作用。 (4) 开发一个计算模型，用于预测研究参数范围内碳纳米管组织的温度分布。碳纳米管辅助激光疗法的成功开发可能会对未来去除肿瘤和抗癌治疗的成功产生重大影响。因此，这项调查可能会产生广泛的影响和巨大的价值。该研究还将评估这些治疗在细胞活力和 HSP 表达方面的功效，这将解决组织复发的可能性。此外，该项目还包括开发一门新课程、为高中生建立一个外展计划、为本科生和研究生工程项目中的女性举办一系列辅导研讨会。