Characterization and Model Development for the Cellular Response to Nanotube-Mediated Laser Therapy

0731108Rylander该项目的目标是表征和模拟碳纳米管（CNT）的热特性，将热量传递给癌细胞，作为根除肿瘤的一种手段。有四个具体目标：（1）测量在含有（CNT）碳纳米管的溶液中激光照射的细胞的热传递、细胞死亡和热休克蛋白（HSP）表达（评价将考虑管结构、支化、树枝状形成和浓度的影响），（2）测定具有CNT的模体中的温度分布，（3）测量与管相关的光学特性和热参数以及它们与组织的相互作用，以及（4）开发一个计算模型，用于预测在所研究的参数范围内碳纳米管组织中的温度分布。碳纳米管辅助激光治疗的成功开发可能对未来用于去除肿瘤和对抗癌症的治疗方法的成功。因此，调查可能会产生广泛的影响和巨大的价值。该研究还将评估这些治疗在细胞活力和HSP表达方面的疗效，这将解决组织复发的可能性。此外，该项目还包括开发一门新课程，为高中生建立一个外联方案，为本科和研究生工程专业的妇女举办一系列辅导研讨会。

0731108RylanderThe goal of the project is to characterize and model the thermal properties of carbon nanotubes (CNT) for delivering heat to cancer cells as a means to eradicate tumors. There are four specific aims: (1) measures of heat delivery, cell death and heat shock protein (HSP) expression for laser irradiated cells in solution with (CNT) carbon nanotubes (evaluations will consider the influence of tube structure, branching, dendritic formations and concentration), (2) determine temperature distributions in phantoms with CNT, (3) measure optical properties and thermal parameters associated with the tubes and their interaction with tissue, and (4) develop a computational model for predicting temperature distribution in tissue with CNT over the parametric range studied.The successful development of CNT assisted laser therapy could have substantial influence on the success of future treatments adopted for removing tumors and fighting cancer. As such, the investigation could have broad impact with tremendous value. The study will also evaluate the efficacy of these treatments in terms of both cell viability and HSP expression, which will address the potential for tissue recurrence. Also, the project also includes the development of a new course, establishing an outreach program for high school students, a mentoring seminar series for women in both undergraduate and graduate engineering programs.