Fragment Based Screening for new Antibiotics by Protein X-Ray Crystallography

通过蛋白质 X 射线晶体学基于片段筛选新抗生素

• 批准号: FT0990287
• 负责人: A/Prof Aaron Oakley
• 金额: $ 48.96万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-25 至 2014-01-24
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT0990287
• 关键词: Fragment; Based; Screening; new; Antibiotics

Due in part to rising levels of antibiotic resistance, the death toll from pathogenic bacteria is expected to skyrocket over the next 15 years. There is therefore a pressing need for new antibiotics to treat bacterial infection. This project will use a relatively new discovery tool called fragment based screening to discover a new generation of antibacterial agents. This tool will allow for the rapid economical discovery of new drugs, and will complement other investments in Australian biotechnology infrastructure.

部分由于抗生素耐药性水平的上升，预计致病细菌的死亡人数将在未来15年内飙升。因此，迫切需要新的抗生素来治疗细菌感染。该项目将使用一种相对较新的发现工具，称为基于片段的筛选，以发现新一代抗菌剂。这一工具将使新药的快速经济发现成为可能，并将补充澳大利亚生物技术基础设施的其他投资。