Development of Robust Strategies for Polymer Syntheses and Application to the Preparation of Functionalized Macromolecular Assemblies - Responsive Janus Nanostructures

稳健的聚合物合成策略的开发及其在功能化大分子组装体制备中的应用 - 响应性 Janus 纳米结构

• 批准号: 184484875
• 负责人: Professor Dr. Axel Müller
• 金额: --
• 依托单位: Department of Chemistry and Biochemistry
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/184484875?language=en
• 关键词: Development; Robust; Strategies; Polymer; Syntheses

The overarching aim of this project is to combine the core competencies of 3 research laboratories in the France, Germany and the United States to investigate the development of robust synthetic strategies for functionalized polymers and apply these novel materials/processes to the preparation of Janus macromolecular assemblies. A driving force for this effort is the application of architecturally-defined soft materials to address resource, health and energy issues. This is a transnational problem and can be addressed most efficiently with multi-national teams. The challenge of matching functional group requirements with efficient synthetic approaches is perhaps best illustrated by the synthesis of Janus macromolecules, nanoparticles and nano-objects. While these materials have great promise in a range of industrial and research settings, there is an increasing need to develop strategies for their construction. An underlying theme of this project is to develop novel synthetic approaches that rely on high yielding and user friendly chemistry, so called “click” reactions to prepare these materials in a facile and efficient manner. Not only will these efforts expand synthetic methodologies in a fundamental sense, but they will greatly increase the range of Janus structures that can be prepared while the simplified techniques will allow a much wider spectrum of researcher’s access to these important material class. We propose to combine living polymerization techniques such as anionic or controlled radical vinyl polymerization and ring opening polymerization of lactones/carbonates/lactides, etc. with efficient functionalization chemistry such as thiol-ene, azide crosslinking, etc. to access tailor-made, multifunctional Janus materials. This will dramatically impact and enhance the development of a fundamental understanding of Janus materials and their use in efficient energy generation/storage, disease detection/treatment, robust sensor systems, etc. The innovation afforded through the discovery and utilization of new synthetic reagents, programmable functional groups and novel polymeric structures is significant and if successful will greatly increase the accessibility of Janus materials to as wide a group of researchers as possible.

该项目的总体目标是联合收割机的核心竞争力的3个研究实验室在法国，德国和美国的功能化聚合物的强大的合成策略的发展和应用这些新的材料/工艺制备Janus大分子组装。这一努力的驱动力是建筑定义的软材料的应用，以解决资源，健康和能源问题。这是一个跨国问题，可以通过多国团队最有效地解决。Janus大分子、纳米颗粒和纳米物体的合成也许最好地说明了将官能团要求与高效合成方法相匹配的挑战。虽然这些材料在一系列工业和研究环境中具有很大的前景，但越来越需要制定其构建策略。该项目的一个基本主题是开发新的合成方法，这些方法依赖于高产和用户友好的化学反应，即所谓的“点击”反应，以简单有效的方式制备这些材料。这些努力不仅将从根本上扩展合成方法，而且将大大增加可以制备的Janus结构的范围，而简化的技术将允许更广泛的研究人员访问这些重要的材料类别。我们建议将联合收割机活性聚合技术（如阴离子或受控自由基乙烯基聚合和内酯/碳酸酯/丙交酯的开环聚合等）与有效的官能化化学（如硫醇-烯、叠氮化物交联等）相结合，以获得定制的多功能Janus材料。这将极大地影响和促进对Janus材料及其在高效能源产生/储存、疾病检测/治疗、强大传感器系统等方面的应用的基本理解的发展。可编程官能团和新型聚合物结构是重要的，如果成功，将大大增加Janus材料的可及性，尽可能多的研究人员。