Numerical investigation of leukocyte binding in the human vasculature

人体脉管系统中白细胞结合的数值研究

• 批准号: 184593547
• 负责人: Dr. Marco Ellero
• 金额: --
• 依托单位: Lehrstuhl für Aerodynamik und Strömungsmechanik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/184593547?language=en
• 关键词: Numerical; investigation; leukocyte; binding; human

This project is based around the theme of atherosclerosis, in particular how this disease develops and progresses. This topic is of great interest to the world over due to the significant pressure this puts on health and monetary systems. In this project we aim to build a frame work for studying the initiation of this disease via a coupled particle – stochastic binding model. In particular we aim to model the transport of blood borne particles in realistic carotid bifurcation geometry utilising SPH particle methods. This transport model for particles, in particular leukocytes, will be coupled to an endothelial cell receptor binding model in order to link the transport and surface biology. Validation of the receptor binding model is proposed via published experimental models of leukocyte binding in both a backwards facing step and axisymmetric expansion flow chamber. This investigation will allow advances in the understanding of leukocyte-receptor binding and potentially identify conditions which are adverse from a mechanobiological perspective.

这个项目是基于动脉粥样硬化的主题，特别是这种疾病如何发展和进展。由于这给卫生和货币体系带来巨大压力，全世界都对这一主题非常感兴趣。本项目旨在建立一个通过粒子-随机结合耦合模型来研究该疾病发生的框架。特别是，我们的目标是利用SPH粒子方法在现实的颈动脉分叉几何形状的血液传播粒子的运输模型。颗粒，特别是白细胞的这种运输模型将与内皮细胞受体结合模型耦合，以将运输和表面生物学联系起来。验证的受体结合模型提出了通过发表的实验模型，白细胞结合在一个面向后的步骤和轴对称膨胀流动室。这项调查将允许在白细胞受体结合的理解和潜在的识别条件是不利的从机械生物学的角度来看，进步。