CAREER: Modeling Acetyl-CoA Synthase - Novel Bioinorganic Chemistry at a Dinuclear Site

这项由无机化学、生物无机化学和金属有机化学项目颁发的职业奖支持了密歇根州立大学埃里克·霍格教授对乙酰辅酶A合成酶活性部位进行建模的工作。这种不同寻常的酶允许某些有机体将二氧化碳作为唯一的碳源。模型络合物的制备将有助于更好地了解乙酰辅酶A合成酶的活性部位和反应机理。最终，这项工作将提供有关乙酰-辅酶A生物合成和酶的C1/C2化学的重要信息。这项研究中整合了一个旨在改进本科生物化学课程的教育组成部分。该计划的一个主要目的是开发和利用基于计算机的实验模块，使学生能够应用课堂上学到的概念，演示本课程所涵盖信息的实际应用，并使他们接触到现代生物化学研究所需的许多新技术。

This CAREER award by the Inorganic, Bioinorganic, and Organometallic Chemistry program supports work by Professor Eric Hegg at the Michigan State University to model the active site of acetyl-CoA synthase. This unusual enzyme allows certain organisms to use carbon dioxide as their sole carbon source. Model complexes will be prepared that will lead to a better understanding of the active site and the reaction mechanism of acetyl-CoA synthase. Ultimately this work will provide important information concerning acetyl-CoA biosynthesis and enzymatic C1/C2 chemistry.Integrated within this research is an educational component designed to improve undergraduate biochemistry courses. A major thrust of this plan is to develop and utilize computer-based laboratory modules that will allow students to apply the concepts learned in class, demonstrate real-world applications of the information covered in the course, and expose them to the many new technologies required in modern biochemical research.