CAREER: Modeling Acetyl-CoA Synthase - Novel Bioinorganic Chemistry at a Dinuclear Site

这项由无机，生物无机和有机化学计划颁发的职业奖支持密歇根州立大学的Eric Hegg教授模拟乙酰辅酶A合酶活性位点的工作。 这种不寻常的酶允许某些生物使用二氧化碳作为其唯一的碳源。 将准备模型复合物，这将导致更好地了解乙酰辅酶A合酶的活性位点和反应机制。 最终，这项工作将提供有关乙酰辅酶A的生物合成和酶C1/C2 chemistry.Integrated在这项研究中是一个教育组成部分，旨在提高本科生生物化学课程的重要信息。 该计划的一个主要目标是开发和利用基于计算机的实验室模块，使学生能够应用在课堂上学到的概念，展示课程中所涵盖的信息的实际应用，并使他们接触到现代生物化学研究所需的许多新技术。

This CAREER award by the Inorganic, Bioinorganic, and Organometallic Chemistry program supports work by Professor Eric Hegg at the Michigan State University to model the active site of acetyl-CoA synthase. This unusual enzyme allows certain organisms to use carbon dioxide as their sole carbon source. Model complexes will be prepared that will lead to a better understanding of the active site and the reaction mechanism of acetyl-CoA synthase. Ultimately this work will provide important information concerning acetyl-CoA biosynthesis and enzymatic C1/C2 chemistry.Integrated within this research is an educational component designed to improve undergraduate biochemistry courses. A major thrust of this plan is to develop and utilize computer-based laboratory modules that will allow students to apply the concepts learned in class, demonstrate real-world applications of the information covered in the course, and expose them to the many new technologies required in modern biochemical research.