CAREER: Modeling Acetyl-CoA Synthase - Novel Bioinorganic Chemistry at a Dinuclear Site
职业:乙酰辅酶A合酶建模——双核位点的新型生物无机化学
基本信息
- 批准号:0739356
- 负责人:
- 金额:$ 24.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-08-31 至 2010-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This CAREER award by the Inorganic, Bioinorganic, and Organometallic Chemistry program supports work by Professor Eric Hegg at the Michigan State University to model the active site of acetyl-CoA synthase. This unusual enzyme allows certain organisms to use carbon dioxide as their sole carbon source. Model complexes will be prepared that will lead to a better understanding of the active site and the reaction mechanism of acetyl-CoA synthase. Ultimately this work will provide important information concerning acetyl-CoA biosynthesis and enzymatic C1/C2 chemistry.Integrated within this research is an educational component designed to improve undergraduate biochemistry courses. A major thrust of this plan is to develop and utilize computer-based laboratory modules that will allow students to apply the concepts learned in class, demonstrate real-world applications of the information covered in the course, and expose them to the many new technologies required in modern biochemical research.
由无机、生物无机和有机金属化学项目颁发的CAREER奖支持密歇根州立大学Eric Hegg教授对乙酰辅酶a合成酶活性位点的建模工作。这种不寻常的酶允许某些生物体将二氧化碳作为它们唯一的碳源。模型配合物的制备将有助于更好地了解乙酰辅酶a合成酶的活性位点和反应机制。最终,这项工作将为乙酰辅酶a生物合成和酶促C1/C2化学提供重要信息。本研究整合了一个旨在改善本科生物化学课程的教育组成部分。该计划的主要目标是开发和利用基于计算机的实验模块,使学生能够应用课堂上学到的概念,展示课程所涵盖信息的实际应用,并使他们接触到现代生化研究所需的许多新技术。
项目成果
期刊论文数量(0)
专著数量(0)
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Eric Hegg其他文献
Eric Hegg的其他文献
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{{ truncateString('Eric Hegg', 18)}}的其他基金
CAREER: Modeling Acetyl-CoA Synthase - Novel Bioinorganic Chemistry at a Dinuclear Site
职业:乙酰辅酶A合酶建模——双核位点的新型生物无机化学
- 批准号:
0348777 - 财政年份:2004
- 资助金额:
$ 24.63万 - 项目类别:
Continuing Grant
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