STTR PHASE I: Selective Bio-Molecule Filtration Media Formulated Using Vapor-Phase Deposition Technology

这项小型企业技术转让（STTR）第一阶段提案将开发一种对无纺布纤维和纤维基系统进行保型涂层的工艺，以选择性地去除流体中的有毒病原体。由这些纤维制成的纤维和织物的化学处理表面将能够过滤、捕获和分离流体流中的有害生物分子，如水、血液和其他类型的污染流体。该研究将为提出的原子层沉积新膜沉积工艺提供新的可能性，该工艺允许以选定的顺序沉积化学物质的单层和各种膜的组合，以构建具有目标性能的所需最终膜结构。如果开发成功，这项技术的更广泛影响将是减轻生物危害。化学和生物毒素通过流体介质的传播是对世界各地人口的主要威胁，因为各种病毒和病原体可以通过使用受污染的水直接摄入。同样，受污染的血液会对患者造成严重的健康危害。恐怖分子发动生化战争的威胁是一个主要的社会问题。因此，这项研究一旦成功完成并商业化，将对人类健康、减轻恐怖主义威胁、涉及输血的医院治疗、重大事故（火灾、爆炸等）或工业场所化学品泄漏后的场地净化、霍乱、伤寒、癣等水媒疾病和洪水后其他健康危害的传播等方面产生重大影响。

This Small Business Technology Transfer (STTR) Phase I proposal will develop a process for conformally coating non-woven fibers and fiber-based systems in order to selectively remove toxic pathogens from fluid streams. The chemically treated surfaces of fibers and fabrics made from these fibers will be able to filter, capture and separate hazardous bio-molecules from the fluid streams, such as water, blood and other types of contaminated fluids. The research will provide new insights into the possibilities available with the proposed novel film deposition process of atomic layer deposition, which permits deposition of single monolayers of a chemical and combinations of various films in selected sequence to build a desired final film structure with targeted properties.The broader impacts of this technology, if developed successfully, will be in the bio-hazard mitigation. Transmittance of chemical and biological toxins through fluid media is a major threat to human populations around the world, as the various kinds of viruses and pathogens can be directly ingested through the use of contaminated water. Similarly, contaminated blood can cause serious health hazard for patients. The threat of biochemical warfare by terrorists is a major societal concerns. Thus this research, when successfully completed and commercialized, will have a major impact on human health, mitigation of terrorist threats, hospital treatments involving blood transfusion, decontamination of sites after a major accident (fire, explosion, etc.) or chemical spills at industrial locations, spread of water-borne diseases such as cholera, typhoid, ringworms and other health hazards after floods, etc.