SBIR Phase I: Silver Nanopillar patterned substrate for surface enhanced fluorescent detection of carbohydrate microarrays

SBIR 第一阶段：用于碳水化合物微阵列表面增强荧光检测的银纳米柱图案基底

• 批准号: 0741155
• 负责人: Xichun Zhou
• 金额: $ 10万
• 依托单位: ADA Technologies, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0741155&HistoricalAwards=false
• 关键词: SBIR; Phase; Silver; Nanopillar; patterned

This Small Business Innovation Research (SBIR) Phase I research project aims to develop a carbohydrate microarray platform that takes advantage of the generation of surface plasmon by silver nanopillars to excite fluorophores above the surface of the microarray to perform detection of binding by proteins. A platform for querying the binding to carbohydrate moieties would open the door to a better understanding of the important role that carbohydrates play in the regulation of cell signaling and inter cellular communication. Such events not only play a role in the normal functions of the body, but are also intimately involved in the disease process.Currently the information regarding the interaction of proteins with carbohydrates is generated using techniques such as nuclear magnetic resonance (NMR). As mentioned above, the binding of proteins and carbohydrates constitutes a very important biological phenomenon, and thus the development of a carbohydrate microarray for querying such binding events would be of significant value to the scientific community.

这项小企业创新研究（SBIR）第一阶段研究项目旨在开发一种碳水化合物微阵列平台，该平台利用银纳米柱产生表面等离子体激发微阵列表面上方的荧光团来检测蛋白质的结合。一个查询与碳水化合物部分结合的平台将为更好地理解碳水化合物在调节细胞信号传导和细胞间通信中的重要作用打开大门。这些事件不仅在身体的正常功能中起作用，而且与疾病的发生过程密切相关。目前，关于蛋白质与碳水化合物相互作用的信息是通过核磁共振（NMR）等技术产生的。如上所述，蛋白质与碳水化合物的结合是一种非常重要的生物现象，因此开发用于查询这种结合事件的碳水化合物微阵列对科学界具有重要价值。