Design of nano- and microparticles by controlled micro-scale fluid flows

通过受控微尺度流体流动设计纳米和微米颗粒

• 批准号: 0741885
• 负责人: Ryan Hayward
• 金额: $ 5万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0741885&HistoricalAwards=false
• 关键词: Design; nano; microparticles; controlled; micro

National Science Foundation - Division of Chemical &Transport Systems - Particulate & Multiphase Processes Program (1415)Proposal Number: 0741885Principal Investigator: Hayward, RyanAffiliation: University of Massechusetts AmherstProposal Title: Design of nano- and microparticles by controlled micro-scale fluid flowsIntellectual MeritIn this research program, a simple and flexible approach to prepare nano- and microparticles with new morphologies and multiple functionalities will be developed. This method relies on the use of micro-scale fluid flows to create droplets of organic solvents with very regular sizes. If the droplets contain dissolved polymers and/or dispersed nanoparticles, then simply by removing the organic solvent, nearly monodisperse collections of solid particles can be prepared. By working with well defined droplet sizes, fundamental questions about how phase separation and interfacial segregation occur in these droplets as the solvent is removed can be systematically addressed, and new particles with interesting morphologies and enhanced functionalities can be produced.Specifically, the goals of the project are to:1) Understand the behavior of amphiphilic block copolymers dissolved in a shrinking droplet of organic solvent, and use this approach to prepare new polymeric assemblies, such as hexosomes and dendritic particles2) Prepare multifunctional micro- and nanoparticles that serve as fluorescent barcodes or combine complementary properties of different types of nanoparticles 3) Determine how aggregation and interfacial segregation of nanoparticles within composite particles can be tuned by factors such as the interactions between nanoparticle ligands and the composite particle matrixBroader ImpactThe scientific outcomes of the proposed work will contribute to our basic understanding of phase separation in composite micro- and nanoparticles, and result in formation of novel particles that may find applications in drug delivery and cancer therapy. Elements of this work will be incorporated into an outreach program at UMass called Science & Engineering Saturdays, which provides opportunities for K-12 science teachers to learn about areas of current research interest, including microfluidics and nanotechnology. Undergraduate and graduate students will learn about interdisciplinary and technologically-important areas of soft materials and nanotechnology, both in a research and a classroom setting. Finally, the program will provide the student community at UMass the opportunity for solid introductory training in an area that is too often neglected in graduate science education: how to teach effectively. This experience will provide the next generation of science educators with a working knowledge of effective teaching practices that extend beyond the traditional lecture format, such as active and project-based learning. By doing so, this program seeks to improve the quality of science education, and its accessibility to a diverse audience, at programs throughout the country.

国家科学基金会-化学品运输系统部门-颗粒多相过程计划（1415）提案编号：0741885主要研究员：海沃德、瑞安附属机构： 马萨诸塞大学阿默斯特分校提案标题：通过控制微尺度流体流动设计纳米和微米颗粒智力优势在这项研究计划中，将开发一种简单灵活的方法来制备具有新形态和多种功能的纳米和微米颗粒。这种方法依赖于使用微尺度流体流来产生具有非常规则尺寸的有机溶剂液滴。如果液滴含有溶解的聚合物和/或分散的纳米颗粒，则简单地通过去除有机溶剂，可以制备固体颗粒的几乎单分散的集合。通过使用定义明确的液滴尺寸，可以系统地解决溶剂去除时这些液滴中如何发生相分离和界面分离的基本问题，并可以生产具有有趣形态和增强功能的新颗粒。具体而言，该项目的目标是：1）了解两亲性嵌段共聚物溶解在有机溶剂的收缩液滴中的行为，并使用这种方法制备新的聚合物组装体，2）制备用作荧光条形码或联合收割机的不同类型的纳米颗粒的互补性质的多功能微米颗粒和纳米颗粒3）确定复合颗粒内纳米颗粒的聚集和界面分离如何通过纳米颗粒配体和复合颗粒之间的相互作用等因素进行调节matrixBroader Impact所提出的工作的科学成果将有助于我们对复合微米和纳米颗粒中相分离的基本理解，并导致可能在药物输送和癌症治疗中应用的新型颗粒的形成。这项工作的内容将被纳入马萨诸塞大学的一个名为“科学工程星期六”的推广计划，该计划为K-12科学教师提供了了解当前研究兴趣领域的机会，包括微流体和纳米技术。本科生和研究生将在研究和课堂环境中学习软材料和纳米技术的跨学科和技术重要领域。最后，该计划将提供在马萨诸塞大学的学生社区的机会，在一个领域，这是太经常被忽视的研究生科学教育坚实的入门培训：如何有效地教学。这种经验将为下一代科学教育工作者提供有效的教学实践的工作知识，这些教学实践超越了传统的讲座形式，例如主动和基于项目的学习。通过这样做，该方案旨在提高科学教育的质量，并在全国各地的方案中向不同的受众提供科学教育。