Design of nano- and microparticles by controlled micro-scale fluid flows

通过受控微尺度流体流动设计纳米和微米颗粒

• 批准号: 0741885
• 负责人: Ryan Hayward
• 金额: $ 5万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0741885&HistoricalAwards=false
• 关键词: Design; nano; microparticles; controlled; micro

National Science Foundation - Division of Chemical &Transport Systems - Particulate & Multiphase Processes Program (1415)Proposal Number: 0741885Principal Investigator: Hayward, RyanAffiliation: University of Massechusetts AmherstProposal Title: Design of nano- and microparticles by controlled micro-scale fluid flowsIntellectual MeritIn this research program, a simple and flexible approach to prepare nano- and microparticles with new morphologies and multiple functionalities will be developed. This method relies on the use of micro-scale fluid flows to create droplets of organic solvents with very regular sizes. If the droplets contain dissolved polymers and/or dispersed nanoparticles, then simply by removing the organic solvent, nearly monodisperse collections of solid particles can be prepared. By working with well defined droplet sizes, fundamental questions about how phase separation and interfacial segregation occur in these droplets as the solvent is removed can be systematically addressed, and new particles with interesting morphologies and enhanced functionalities can be produced.Specifically, the goals of the project are to:1) Understand the behavior of amphiphilic block copolymers dissolved in a shrinking droplet of organic solvent, and use this approach to prepare new polymeric assemblies, such as hexosomes and dendritic particles2) Prepare multifunctional micro- and nanoparticles that serve as fluorescent barcodes or combine complementary properties of different types of nanoparticles 3) Determine how aggregation and interfacial segregation of nanoparticles within composite particles can be tuned by factors such as the interactions between nanoparticle ligands and the composite particle matrixBroader ImpactThe scientific outcomes of the proposed work will contribute to our basic understanding of phase separation in composite micro- and nanoparticles, and result in formation of novel particles that may find applications in drug delivery and cancer therapy. Elements of this work will be incorporated into an outreach program at UMass called Science & Engineering Saturdays, which provides opportunities for K-12 science teachers to learn about areas of current research interest, including microfluidics and nanotechnology. Undergraduate and graduate students will learn about interdisciplinary and technologically-important areas of soft materials and nanotechnology, both in a research and a classroom setting. Finally, the program will provide the student community at UMass the opportunity for solid introductory training in an area that is too often neglected in graduate science education: how to teach effectively. This experience will provide the next generation of science educators with a working knowledge of effective teaching practices that extend beyond the traditional lecture format, such as active and project-based learning. By doing so, this program seeks to improve the quality of science education, and its accessibility to a diverse audience, at programs throughout the country.

National Science Foundation - Division of Chemical &Transport Systems - Particulate & Multiphase Processes Program (1415)Proposal Number: 0741885Principal Investigator: Hayward, RyanAffiliation: University of Massechusetts AmherstProposal Title: Design of nano- and microparticles by controlled micro-scale fluid flowsIntellectual MeritIn this research program, a simple and flexible approach to prepare nano- and将开发具有新形态和多种功能的微粒。这种方法依赖于使用微尺度流体流以产生非常规模的有机溶剂液滴。如果液滴包含溶解的聚合物和/或分散的纳米颗粒，则只需去除有机溶剂，就可以制备几乎单分散的固体溶剂集合。通过使用明确定义的液滴尺寸，可以系统地解决这些液滴中如何进行相位分离和互种​​隔离的基本问题，并且具有有趣的形态和功能增强的新粒子可以产生。并使用这种方法来准备新的聚合物组件，例如六体和树突颗粒2）准备多功能的微颗粒和纳米颗粒，这些微粒和纳米颗粒用作荧光条形码或结合不同类型的纳米颗粒的互补特性3）。配体和复合粒子基质分子影响拟议工作的科学结果将有助于我们对复合微粒和纳米颗粒中相分离的基本理解，并导致形成新的颗粒，这些颗粒可能在药物递送和癌症治疗中发现应用。这项工作的元素将纳入UMass Science＆Engineering星期六的外展计划中，该计划为K-12科学教师提供了了解当前研究兴趣领域的机会，包括微流体和纳米技术。在研究和课堂环境中，本科生和研究生将了解软材料和纳米技术的跨学科和技术重要领域。最后，该计划将为UMASS的学生社区提供在研究生科学教育中经常被忽略的领域进行扎实介绍培训的机会：如何有效教授。这种经验将为下一代科学教育者提供有效的教学实践的工作知识，这些知识超出了传统的演讲形式，例如积极和基于项目的学习。通过这样做，该计划旨在在全国各地的计划中提高科学教育质量及其对多样化受众的可及性。