Structure and Function of Plant Protein Synthesis Initiation Factors: eIF4F and eIFiso4F
植物蛋白合成起始因子:eIF4F 和 eIFiso4F 的结构和功能
基本信息
- 批准号:0745146
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-03-15 至 2011-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Translation of mRNA into protein is an essential molecular process of cellular metabolism. Plant protein synthesis is similar to that of other eukaryotes, but there are differences. The presence of the isozyme form of eIF4F and the apparent lack of regulation by 4E binding proteins (primary regulatory point in mammalian translation) suggest that plants have some fundamental differences, particularly in the regulation of initiation of translation. Elucidating the roles of the isoforms of eIF4F in plants will provide a better understanding of how plants regulate the production of proteins which will lead to improved plants that resist environmental insults or virus infection, and provide better quality protein for food. This research project will be used for the training of high school, community college, undergraduate, graduate and post-doctoral students and the results disseminated through publication and the Factors In Arabidopsis Translation (FIAT) website. The training of undergraduates will be through the Freshman Research Initiative (FRI). The FRI teaches freshman about research and trains them to do research in what are called "research streams". The PI is a stream leader for 25 freshmen students. The students are trained in methods relevant to the PI's research and contribute to the PI's overall research and specifically will contribute to the proposed project. One of the goals of the FRI is to attract and retain students in science, technology, engineering and math (STEM) disciplines.
mRNA转化为蛋白质是细胞代谢的重要分子过程。植物蛋白的合成与其他真核生物相似,但也存在差异。eIF4F同工酶形式的存在和4E结合蛋白(哺乳动物翻译的主要调控点)的明显缺乏表明植物具有一些根本性的差异,特别是在翻译起始的调控方面。阐明eIF4F同工型在植物中的作用将有助于更好地了解植物如何调节蛋白质的产生,从而改进植物,使其能够抵抗环境损害或病毒感染,并为食物提供更优质的蛋白质。本研究项目将用于培养高中、社区学院、本科生、研究生和博士后,研究结果将通过出版物和拟南芥翻译因子(FIAT)网站进行传播。本科生的培训将通过新生研究计划(FRI)进行。FRI教授大一新生关于研究的知识,并训练他们在所谓的“研究流”中进行研究。PI是25名新生的领导。学生将接受与PI研究相关的方法培训,并为PI的整体研究做出贡献,特别是为拟议的项目做出贡献。FRI的目标之一是吸引和留住科学、技术、工程和数学(STEM)学科的学生。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Karen Browning其他文献
Karen Browning的其他文献
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{{ truncateString('Karen Browning', 18)}}的其他基金
CONFERENCE: Post-transcriptional Gene Regulation in Plants to be held July 14-15, 2016 at the Austin Convention Center in Austin, TX
会议:植物转录后基因调控将于 2016 年 7 月 14 日至 15 日在德克萨斯州奥斯汀的奥斯汀会议中心举行
- 批准号:
1631903 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Standard Grant
Function of Plant Protein Synthesis Initiation Factors: eIF4G and eIFiso4G
植物蛋白合成起始因子的功能:eIF4G 和 eIFiso4G
- 批准号:
1052530 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Continuing Grant
The 5th Meeting on Post-Transcriptional Regulation of Plant Gene: Expression to be held June 8-12, 2005 at the University of Texas at Austin.
第五届植物基因转录后调控:表达会议将于 2005 年 6 月 8 日至 12 日在德克萨斯大学奥斯汀分校举行。
- 批准号:
0503730 - 财政年份:2005
- 资助金额:
-- - 项目类别:
Standard Grant
Structure and Function of Plant Protein Synthesis Initiation Factors
植物蛋白合成起始因子的结构和功能
- 批准号:
0214996 - 财政年份:2002
- 资助金额:
-- - 项目类别:
Continuing Grant
Structure of Plant Protein Synthesis Initiation Factors
植物蛋白合成起始因子的结构
- 批准号:
9406601 - 财政年份:1994
- 资助金额:
-- - 项目类别:
Continuing Grant
Structure of Plant Protein Synthesis Initiation Factors
植物蛋白合成起始因子的结构
- 批准号:
9105353 - 财政年份:1991
- 资助金额:
-- - 项目类别:
Standard Grant
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