CRCNS data sharing: Physiological and anatomical properties of hippocampal neurons and connections in vivo

CRCNS 数据共享：海马神经元的生理和解剖特性及其体内连接

• 批准号: 0747873
• 负责人: Gyorgy Buzsaki
• 金额: --
• 依托单位: Rutgers University Newark
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0747873&HistoricalAwards=false
• 关键词: CRCNS; data; sharing; Physiological; anatomical

Proposal No: 0747873 PI: Gyorgy Buzsaki Abstract:This award supports the preparation and sharing of computational neuroscience data as part of an exploratory activity aimed at catalyzing rapid and innovative advances in computational neuroscience and related fields. The data to be shared in this project are physiological and anatomical data from the rat hippocampus, including (1) recordings from hippocampal CA1 neurons during open field foraging, (2) simultaneous intracellular and extracellular in vivo recordings from CA1 pyramidal cells and histological identities of those neurons, (3) quantitative information on the cellular connectivity of the hippocampal formation, and (4) axonal reconstruction data from in vivo preparations. Anatomical and physiological data will be cross-annotated to facilitate browsing and integration, and provided in a form that is compatible with widely used simulators. It is anticipated that these data will be useful for developing anatomically and physiologically realistic neural networks and understanding emergent behavior of neuronal populations, in particular, the mechanisms of memory.

摘要：该奖项支持计算神经科学数据的准备和共享，作为旨在促进计算神经科学及相关领域快速创新进展的探索性活动的一部分。本项目共享的数据是来自大鼠海马的生理和解剖数据，包括：(1)在野外觅食时海马CA1神经元的记录，(2)CA1锥体细胞的细胞内和细胞外的体内同时记录以及这些神经元的组织学特征，(3)海马形成的细胞连通性的定量信息，以及(4)体内制备的轴突重建数据。解剖和生理数据将交叉注释，以方便浏览和整合，并以一种与广泛使用的模拟器兼容的形式提供。预计这些数据将有助于发展解剖学和生理学上真实的神经网络，并理解神经元群体的紧急行为，特别是记忆机制。