SGER: Learning and Representation of Cortical similarity of faces in Individuals with Autistic Spectrum Disorder.

SGER：自闭症谱系障碍患者面部皮质相似性的学习和表征。

• 批准号: 0751008
• 负责人: Stephen Hanson
• 金额: --
• 依托单位: Rutgers University Newark
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0751008&HistoricalAwards=false
• 关键词: SGER; Learning; Representation; Cortical; similarity

The proposal represents an emerging area of computational cognitive neuroscience. It addresses an important issues of how brain learns, and specifically, how learning occurs in fusiform face area (FFA). The claim that the neural information for face processing is located in FFA, recently came under increasing scrutiny, and it needs further investigation using computation neuroscience and high resolution fMRI methodology. This proposal combines high resolution imaging with comprehensive feature selection method to examine the way face stimuli are represented in brain tissue of both neuro-typical and individuals with autistic spectrum disorder (ASD). The specific goal of the proposal is to examine cortical representational differences in individuals with ASD and neuro-typicals with a focus on face diagnostic brain areas (e.g., FFA). Both groups of subjects will attempt to learn the same face orientation task in order to establish any behavioral deficits while their brain scans will be collected. The problems of ASD individual difficulties in learning of face responses are currently not well understood. The current proposal can provide significant insights into the neural substrates of autism, and specifically into the issue of selectivity of FFA and its role in autistic disorder.

该提案代表了计算认知神经科学的一个新兴领域。它解决了一个重要的问题，大脑如何学习，特别是如何学习发生在梭状回区（FFA）。关于面孔加工的神经信息位于FFA的说法最近受到越来越多的关注，需要使用计算神经科学和高分辨率fMRI方法进行进一步的研究。 该建议结合了高分辨率成像与综合特征选择方法，以检查面部刺激在神经典型和自闭症谱系障碍（ASD）个体的脑组织中的表现方式。该提案的具体目标是检查ASD患者和神经典型患者的皮质表征差异，重点是面部诊断脑区（例如，FFA）。 两组受试者将尝试学习相同的面部定向任务，以建立任何行为缺陷，同时收集他们的大脑扫描。ASD个体在学习面部反应方面的困难问题目前还没有得到很好的理解。目前的建议可以提供显着的见解自闭症的神经基板，特别是到FFA的选择性及其在自闭症障碍中的作用的问题。