Carbon Nantotubes as Antimicrobial Agents
碳纳米管作为抗菌剂
基本信息
- 批准号:0756323
- 负责人:
- 金额:$ 24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-08-01 至 2013-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
CBET-0756323P. Van Tassel, Yale UniversityImplantable medical devices/materials are becoming commonplace, often playing major roles in life-saving procedures. Medical device infection continues to be a significant unresolved problem. Materials exhibiting antimicrobial behavior represent an attractive solution, but current strategies involving the sustained delivery of anti-infective agents are sub-optimal due to finite quantity of anti-infective, gradually diminishing rate of release, toxicity of released compound, etc. A superior approach would be a material composed of a permanent, non-leachable antimicrobial substance. The PI and co-PIs propose here to investigate carbon nanotubes (CNT) as potential building blocks for antimicrobial materials. Recently, two of the investigators (LP and ME) have shown CNT to effectively kill bacteria, yet to remain compatible with human cells. These new findings, together with the chemical stability and ease of functionalization typical of carbon nanoscale objects, make CNT potentially attractive as building blocks for antimicrobial materials. However, fundamental knowledge of the CNT antimicrobial effect is currently very limited. For example, the following key fundamental questions remain open: - How do CNT properties - length, diameter, surface functionalization, metal content - influence their antimicrobial activity? - How does CNT presentation - as isolated nanotubes, deposited aggregates, thin films - influence their antimicrobial activity? - By what mechanism(s) do CNT exert antimicrobial activity? The investigators seek here to answer these questions and thereby take the first steps toward engineering CNT-based antimicrobial materials. The focus is on four model pathogens known to infect biomedical devices, and the team begins the project in a unique position of being able to produce low-defect CNT of precisely controlled diameter. Materials capable of destroying harmful pathogens without the use of antibiotics or other potentially harmful (bio)chemical agents could revolutionize health care - yielding an immense impact on the quality of human life. One could also imagine other surfaces - within health care facilities or even households - being rendered anti-infective using the strategies developed here. A mechanistic understanding of the cell-nanotube interaction - here developed in the context of microbes but possibly extended in the future to human cells - could also aid in the development of medical applications such as biosensors, drug delivery, tissue engineering scaffolds, and targeting and destruction of cancer cells. The investigators propose to integrate undergraduate students into the proposed research activities. Students will come from Yale, the University of New Haven, and Albertus Magnus College (all in New Haven). Students from the STARS program at Yale, a program to support undergraduate research for minority and female science/engineering students, are especially sought. The team also proposes to develop an outreach effort to a New Haven public high school by adding Yale Engineering to an existing partnership between the Yale Schools of Medicine and Nursing and the Hill Regional Career High School. The participating undergraduate students will be encouraged to act as mentors to the high school students. Integration of research into the Yale undergraduate and graduate curricula will also have a broad impact. The investigators propose to develop a course module on nanotube synthesis and surface coating consisting of a series of lectures to be given as part of existing undergraduate and graduate courses on nano- and bio-materials. The significance will be an early exposure to state-of-the art methods in nanotechnology, as well as stimulating interdisciplinary classroom interaction.
CBET-0756323P。货车塔塞尔,耶鲁大学植入式医疗设备/材料正变得越来越普遍,往往在挽救生命的过程中发挥重要作用。医疗器械感染仍然是一个重大的未解决问题。表现出抗微生物行为的材料代表了一种有吸引力的解决方案,但是由于抗感染剂的有限量、逐渐降低的释放速率、释放的化合物的毒性等,涉及抗感染剂的持续递送的当前策略是次优的。上级方法将是由永久性、不可浸出的抗微生物物质组成的材料。PI和co-PI在这里建议研究碳纳米管(CNT)作为抗菌材料的潜在构建块。最近,两名研究人员(LP和ME)已经证明CNT可以有效地杀死细菌,但仍然与人类细胞相容。这些新发现,加上碳纳米级物体典型的化学稳定性和易于功能化,使CNT作为抗菌材料的构建块具有潜在的吸引力。然而,CNT抗微生物效果的基本知识目前非常有限。例如,以下关键的基本问题仍然是开放的:-如何做CNT属性-长度,直径,表面功能化,金属含量-影响其抗菌活性?- CNT的表现形式--作为孤立的纳米管、沉积的聚集体、薄膜--如何影响它们的抗菌活性? - CNT通过什么机制发挥抗菌活性?研究人员试图在这里回答这些问题,从而采取第一步工程CNT为基础的抗菌材料。重点是已知感染生物医学设备的四种模型病原体,该团队在能够生产精确控制直径的低缺陷CNT的独特位置开始该项目。 能够在不使用抗生素或其他潜在有害(生物)化学制剂的情况下摧毁有害病原体的材料可能会彻底改变医疗保健-对人类生活质量产生巨大影响。人们也可以想象其他表面-在卫生保健设施甚至家庭-被赋予抗感染使用这里开发的策略。对细胞-纳米管相互作用的机械理解-在这里是在微生物的背景下开发的,但将来可能扩展到人类细胞-也可以帮助开发医学应用,如生物传感器,药物输送,组织工程支架以及靶向和破坏癌细胞。研究人员建议将本科生纳入拟议的研究活动。学生将来自耶鲁大学,纽黑文大学和Albertus Magnus学院(都在纽黑文)。特别寻求来自耶鲁大学STARS项目的学生,该项目旨在支持少数民族和女性科学/工程学生的本科研究。该小组还建议通过将耶鲁工程学院加入耶鲁医学院和护理学院与希尔地区职业高中之间的现有合作伙伴关系,为纽黑文的一所公立高中开展外联工作。参与的本科生将被鼓励担任高中生的导师。 将研究纳入耶鲁大学本科和研究生课程也将产生广泛的影响。研究人员建议开发一个关于纳米管合成和表面涂层的课程模块,该模块由一系列讲座组成,作为现有的纳米和生物材料本科和研究生课程的一部分。其意义将是早期接触到国家的最先进的方法在纳米技术,以及刺激跨学科的课堂互动。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Paul Van Tassel其他文献
Paul Van Tassel的其他文献
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{{ truncateString('Paul Van Tassel', 18)}}的其他基金
An optical waveguide lightmode spectroscopy instrument for research and teaching
用于研究和教学的光波导光模式光谱仪器
- 批准号:
1066994 - 财政年份:2011
- 资助金额:
$ 24万 - 项目类别:
Standard Grant
Travel Support for ACS Symposium "Engineering the Cell-Material Interface", March 24-25, 2010 in San Fransico, California.
为 2010 年 3 月 24 日至 25 日在加利福尼亚州旧金山举行的 ACS 研讨会“细胞材料界面工程”提供旅行支持。
- 批准号:
1021403 - 财政年份:2010
- 资助金额:
$ 24万 - 项目类别:
Standard Grant
Continuous Polyelectrolyte Adsorption under an Applied Electric Potential
施加电势下的连续聚电解质吸附
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0651980 - 财政年份:2007
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Macro-Ions Near Confining Surfaces: Influence on Colloidal Forces
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0434777 - 财政年份:2004
- 资助金额:
$ 24万 - 项目类别:
Continuing Grant
Templated Molecular Recognition Materials: Theory and Simulation
模板化分子识别材料:理论与模拟
- 批准号:
0228400 - 财政年份:2003
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$ 24万 - 项目类别:
Continuing Grant
Templated Molecular Recognition Materials: Theory and Simulation
模板化分子识别材料:理论与模拟
- 批准号:
0337829 - 财政年份:2003
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$ 24万 - 项目类别:
Continuing Grant
A CECAM Workshop on Metastability and Landscapes in Complex (Materials) Systems, Lyons, France, May 22 - 24, 2003
CECAM 复杂(材料)系统亚稳定性和景观研讨会,法国里昂,2003 年 5 月 22 - 24 日
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0332069 - 财政年份:2003
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$ 24万 - 项目类别:
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A Workshop on Nanoscale Science and Engineering: Common Challenges and Integrative Opportunities Across Areas of Research, Programming and Industry
纳米科学与工程研讨会:研究、编程和工业领域的共同挑战和综合机遇
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0240561 - 财政年份:2002
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Workshop on Grand Challenges in Nanoscale Science and Engineering
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0129012 - 财政年份:2001
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Midwest Thermodynamics and Statistical Mechanics Conference, May 17-18, 1999, Detroit, Michigan
中西部热力学和统计力学会议,1999 年 5 月 17-18 日,密歇根州底特律
- 批准号:
9978576 - 财政年份:1999
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