An optical waveguide lightmode spectroscopy instrument for research and teaching

用于研究和教学的光波导光模式光谱仪器

• 批准号: 1066994
• 负责人: Paul Van Tassel
• 金额: $ 2.78万
• 依托单位: Yale University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1066994&HistoricalAwards=false
• 关键词: optical; waveguide; lightmode; spectroscopy; instrument

CBET-1066994Van TasselIntellectual Merit: Many problems in the chemical, materials, and biomedical sciences and engineering involve adsorption of large molecules at the solid-liquid interface. Optical waveguide lightmode spectroscopy (OWLS) is a premier technique allowing for the real-time detection of macromolecular adsorption at the solid liquid interface. The PIs group has used the OWLS technique extensively to build a research program focusing on bio-interfacial engineering. However, of the two original OWLS instruments, one no longer functions and the other suffers severely from an antiquated computer interface system. MicroVacuum, the commercial manufacturer of OWLS technology, has offered the PI a completely new instrument with a heavy discount making it economically as well as scientifically advantageous to purchase a new instrument rather than repair/ upgrade either of the old instruments. This project provides the funds to acquire a new OWLS 210 system from MicroVacuum. The new instrument will be used i) to complete the current NSF funded project Carbon nanotubes as antimicrobial agents (CBET-0756323), ii) to begin work on four new projects, iii) as the primary experimental tool for undergraduate researchers in the PI's lab, and iv) as a teaching tool in the Yale Undergraduate Chemical Engineering Laboratory course. Broader Impact: A new OWLS instrument in the PI's lab will have a broad impact in several ways. Scientific impact will come from the currently funded project and four new projects. In particular, new nanoscale polyelectrolyte films will emerge that will impact areas such as separations, energy storage/delivery, cell-based diagnostics, and tissue engineering. OWLS has proven to be a straightforward technique for undergraduate researchers; their involvement in these new projects will bring forth a large educational impact. Finally, use of the new instrument is proposed for an experiment in adsorption kinetics in Yale's Undergraduate Chemical Engineering Laboratory beginning in Spring 2011.

CBET-1066994 Van Tassel智力优点：化学、材料和生物医学科学和工程中的许多问题都涉及到固液界面上大分子的吸附。光波导光模光谱（OWLS）是一种重要的技术，可以实时检测大分子在固液界面的吸附。PI小组广泛使用OWLS技术来建立一个专注于生物界面工程的研究计划。然而，在两个原始的OWLS仪器中，一个不再起作用，另一个受到陈旧的计算机接口系统的严重影响。MicroVacuum是OWLS技术的商业制造商，它为PI提供了一个全新的仪器，并提供了很大的折扣，这使得购买新仪器而不是维修/升级旧仪器在经济上和科学上都是有利的。该项目提供资金从MicroVacuum购买新的OWLS 210系统。新仪器将用于i）完成当前NSF资助的项目碳纳米管作为抗菌剂（CBET-0756323），ii）开始四个新项目的工作，iii）作为PI实验室本科研究人员的主要实验工具，iv）作为耶鲁大学本科化学工程实验室课程的教学工具。更广泛的影响：PI实验室中的新OWLS仪器将在几个方面产生广泛的影响。科学影响将来自目前资助的项目和四个新项目。特别是，新的纳米级薄膜将出现，这将影响分离，能量储存/输送，基于细胞的诊断和组织工程等领域。OWLS已被证明是一个简单的技术为本科生研究人员，他们在这些新项目的参与将带来巨大的教育影响。最后，使用新的仪器提出了在耶鲁大学的本科化学工程实验室在2011年春季开始的吸附动力学实验。