GOALI/Collaborative Research: Design and Manufacturing of Bioactive Surgical Fixation Devices Using Injection Molding of Gradient Cellular Structures

GOALI/合作研究：利用梯度细胞结构注射成型设计和制造生物活性手术固定装置

• 批准号: 0800016
• 负责人: Donggang Yao
• 金额: $ 16.59万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0800016&HistoricalAwards=false
• 关键词: GOALI; Collaborative; Research; Design; Manufacturing

The research objective of this Grant Opportunity for Academic Liaison with Industry (GOALI) Collaborative Research project is to investigate novel surgical fixation devices (screw, anchor, plate, pin, staple, etc.) that not only secure a graft in place, but incorporate bioactive materials such as growth factors, drugs, and cells, intended to promote bone tissue growth. The new devices can eliminate painful secondary operations, adverse effects of permanent implants, and the lack of bioactive features in existing surgical fixation devices. The research addresses challenges in biocompatible, biodegradable and bioactive materials for surgical fixation devices and investigates a new delivery method for bio-reagents through the surgical devices. The approach will be: 1. Identify suitable structural and bioactive materials for a strong fixation device body and efficient bone-tissue healing and growth. 2. Design a new bioactive interference screw, as a specific example and application with required mechanical integrity and bioactivity. 3. Explore a new technique, gradient cellular structure (GCS), to create interconnective porous structure to control screw mechanical strength and assist in bioactive materials delivery. 4. Through testing to find, control, optimize and integrate all required functionalities such as mechanical integrity, material degradation rate, and bioactive reagents delivery rate.If successful, the benefits and broader impacts of this research will be: to replace current passive orthopedic surgery devices with active devices, i.e. the surgical devices not only serve fixation and support purposes but also have curing, healing and tissue-promoting biological functions; a long term research and educational relationship with Arthrex, Inc. will be built for the new technology development and transfer; three doctoral students and two senior design teams will be trained; three project-based learning modules will be created to strengthen the undergraduate mechanical and biomedical engineering curricula, engaging students with design projects in bioactive fixation devices and bio-reagents delivery. New findings from the research will be disseminated in professional journals and at conferences. The project will also be used in specially designed outreach workshops for local high school and community college students, including many underrepresented minority students to showcase high-tech mechanical and polymer engineering applications in biotechnology.

本学术界与工业界（GOALI）合作研究项目的研究目标是研究新型外科固定器械（螺钉、锚、接骨板、销钉、吻合钉等）。其不仅将移植物固定在适当位置，而且包含生物活性材料，例如生长因子、药物和细胞，旨在促进骨组织生长。新器械可以消除疼痛的二次手术、永久性植入物的不良影响以及现有手术固定器械缺乏生物活性特征。该研究解决了用于手术固定装置的生物相容性，生物可降解性和生物活性材料的挑战，并研究了通过手术装置输送生物试剂的新方法。方法将是：1.确定合适的结构和生物活性材料，以获得坚固的固定器械主体和有效的骨组织愈合和生长。2.设计一种新型生物活性界面螺钉，作为一个具体的例子和应用，具有所需的机械完整性和生物活性。3.探索一种新技术，梯度细胞结构（GCS），以创建互连的多孔结构来控制螺钉机械强度并辅助生物活性材料输送。4.通过测试来发现、控制、优化和整合所有所需的功能，如机械完整性、材料降解率和生物活性试剂输送率。如果成功，这项研究的好处和更广泛的影响将是：用有源装置取代现有的无源骨科手术装置，即手术装置不仅具有固定和支撑作用，而且具有治疗作用，愈合和组织促进生物功能;与Arthrex，Inc.建立长期的研究和教育关系。将为新技术的开发和转让建立一个新的技术中心;将培训三名博士生和两个高级设计团队;将创建三个基于项目的学习模块，以加强本科生的机械和生物医学工程课程，让学生参与生物活性固定装置和生物试剂输送方面的设计项目。研究的新发现将在专业期刊和会议上传播。 该项目还将用于为当地高中和社区大学学生特别设计的外联讲习班，其中包括许多代表性不足的少数民族学生，以展示高科技机械和聚合物工程在生物技术中的应用。